[HTML][HTML] Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR …
B Liu, X Deng, Q Jiang, G Li, J Zhang, N Zhang… - Biomedicine & …, 2020 - Elsevier
Highlights•Scoparone improves hepatic inflammation and autophagy in mice with MCD
diet.•Scoparone has an effect on autophag in macrophages, but not hepatocytes.• …
diet.•Scoparone has an effect on autophag in macrophages, but not hepatocytes.• …
Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice
B Liu, X Deng, Q Jiang, G Li, J Zhang, N Zhang… - International …, 2019 - Elsevier
Scoparone, a naturally-occurring, bioactive compound isolated from the Chinese herb
Artemisia capillaria, has been shown to ameliorate hepatotoxicity and cholestasis in liver …
Artemisia capillaria, has been shown to ameliorate hepatotoxicity and cholestasis in liver …
Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy
G Ji, Y Wang, Y Deng, X Li, Z Jiang - Lipids in health and disease, 2015 - Springer
Background Non-alcoholic steatohepatitis (NASH) is one of the leading causes of chronic
liver disease that can progress to liver fibrosis, cirrhosis and eventually hepatocellular …
liver disease that can progress to liver fibrosis, cirrhosis and eventually hepatocellular …
Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation
W Chen, Z Zhang, Z Yao, L Wang, F Zhang… - International …, 2018 - Elsevier
Liver fibrosis is a reversible pathophysiological process correlated with intense repair and
cicatrization mechanisms, and its end-stage cirrhosis is responsible for high morbidity and …
cicatrization mechanisms, and its end-stage cirrhosis is responsible for high morbidity and …
[HTML][HTML] Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway
HJ Kim, Y Joe, SK Kim, SU Park, J Park, Y Chen… - Free Radical Biology …, 2017 - Elsevier
Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic
syndrome, has emerged as one of the most common causes of chronic liver disease in …
syndrome, has emerged as one of the most common causes of chronic liver disease in …
[HTML][HTML] CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy
Background & Aims CXC chemokine receptor 3 (CXCR3) is involved in virus-related chronic
liver inflammation. However, the role of CXCR3 in non-alcoholic steatohepatitis (NASH) …
liver inflammation. However, the role of CXCR3 in non-alcoholic steatohepatitis (NASH) …
Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition
SH Kim, G Kim, DH Han, M Lee, I Kim, B Kim, KH Kim… - Autophagy, 2017 - Taylor & Francis
Impairment in macroautophagy/autophagy flux and inflammasome activation are common
characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack of approved …
characteristics of nonalcoholic steatohepatitis (NASH). Considering the lack of approved …
[HTML][HTML] Pro-inflammatory CXCR3 impairs mitochondrial function in experimental non-alcoholic steatohepatitis
Mitochondrial dysfunction plays a crucial role in the development of non-alcoholic
steatohepatitis (NASH). However, the regulator of mitochondrial dysfunction in the …
steatohepatitis (NASH). However, the regulator of mitochondrial dysfunction in the …
Doxazosin attenuates liver fibrosis by inhibiting autophagy in hepatic stellate cells via activation of the PI3K/Akt/mTOR signaling pathway
AY Xiu, Q Ding, Z Li, CQ Zhang - Drug design, development and …, 2021 - Taylor & Francis
Purpose To investigate the effect of doxazosin on autophagy and the activation of hepatic
stellate cells (HSCs) in vivo and in vitro and determine the underlying mechanism. Methods …
stellate cells (HSCs) in vivo and in vitro and determine the underlying mechanism. Methods …
Ampelopsin attenuates carbon tetrachloride-induced mouse liver fibrosis and hepatic stellate cell activation associated with the SIRT1/TGF-β1/Smad3 and autophagy …
JQ Ma, YZ Sun, QL Ming, ZK Tian, HX Yang… - International …, 2019 - Elsevier
Ampelopsin (Amp), a natural flavonoid found in the vine tea of Ampelopsis grossedentata,
exhibited anti-cancer, anti-oxidant, anti-inflammatory, anti-apoptosis and hepatoprotective …
exhibited anti-cancer, anti-oxidant, anti-inflammatory, anti-apoptosis and hepatoprotective …