Conventional cytotoxic chemotherapy used to treat acute lymphoblastic leukemia (ALL)
results in high cure rates in pediatric patients but is suboptimal in the treatment of adult …

Much progress has been made in understanding the biology of and therapy for acute
lymphoblastic leukemia (ALL). This progress has translated into the recognition of several …

In the early 1980s, adult acute lymphoblastic leukemia (ALL) was a rarely curable disease
with overall survival< 10%. After adapting combinations employed by pediatric groups, the …

BACKGROUND Much progress has been made in understanding the biology of acute
lymphoblastic leukemia (ALL). This has translated into the recognition of several subgroups …

Acute lymphoblastic leukemia (ALL), a clonal expansion of hematopoietic blasts, is a highly
heterogeneous disease comprising many entities for which distinct treatment strategies are …

Acute lymphoblastic leukemia (ALL), the most common type of cancer in children, is a
heterogeneous disease in which many genetic lesions result in the development of multiple …

Progress in adult acute lymphoblastic leukemia (ALL) treatment has been met with
challenge until recently. A steady improvement in outcomes is being witnessed among …

Acute lymphoblastic leukemia (ALL) is characterized by chromosomal translocations and
somatic mutations that lead to leukemogenesis. The incorporation of pediatric-type regimens …

Importance Remarkable progress has occurred in understanding the pathophysiology and
in developing improved personalized therapies in adult acute lymphoblastic leukemia (ALL) …

Acute lymphoblastic leukemia (ALL) has served as a model for the cure of neoplasia by
chemotherapy. Current treatment results in complete remissions in 80% to 90% of cases …