Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

Epigenetics refers to stable alterations in gene expression with no underlying modifications
in the genetic sequence and is best exemplified by differentiation, in which multiple cell …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

The epigenetic regulation of DNA-templated processes has been intensely studied over the
last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA …

Since its discovery in 1983, the epigenetics of human cancer has been in the shadows of
human cancer genetics. But this area has become increasingly visible with a growing …

There are three connected molecular mechanisms of epigenetic cellular memory in
mammalian cells: DNA methylation, histone modifications, and RNA interference. The first …

The past 15 years have seen an explosion of discoveries related to the cellular regulation of
phenotypes through epigenetic mechanisms. This regulation provides a software that …

Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …

Epigenetic and genetic alterations have long been thought of as two separate mechanisms
participating in carcinogenesis. A recent outcome of whole exome sequencing of thousands …

Deregulation of gene expression is a hallmark of cancer. Although genetic lesions have
been the focus of cancer research for many years, it has become increasingly recognized …