ABSTRACT HIV-1 integrase (IN) has a noncatalytic function in virion maturation through its
binding to the viral RNA genome (gRNA). Class II IN substitutions inhibit IN-gRNA binding …

A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations,
referred to as class II substitutions, exhibit pleiotropic effects during virus replication …

While an essential role of HIV-1 integrase (IN) for integration of viral cDNA into human
chromosome is established, studies with IN mutants and allosteric IN inhibitors (ALLINIs) …

Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …

The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the
reverse-transcribed viral DNA into the host chromosome. This function of IN has been well …

Recent evidence indicates that inhibition of HIV-1 integrase (IN) binding to the viral RNA
genome by allosteric integrase inhibitors (ALLINIs) or through mutations within IN yields …

Nonenzymatic roles for HIV-1 integrase (IN) at steps prior to the enzymatic integration step
have been reported. To obtain structural and functional insights into the nonenzymatic roles …

Genetic robustness (tolerance of mutation) may be a naturally selected property in some
viruses, because it should enhance adaptability. Robustness should be especially beneficial …

Integrase (IN) from human immunodeficiency virus, type 1 (HIV-1) exerts pleiotropic effects
in the viral replication cycle. Besides integration, IN mutations can impact nuclear import …

HIV-1 integrase (IN) is an essential enzyme for viral infection. Here, we report an extensive π
electron orbital interaction between four amino acids, W132, M178, F181 and F185, located …