Recent proof-of-concept randomised controlled trials have shown a causal relation between
herpes simplex virus (HSV) type 2 infection and HIV-1 replication in co-infected individuals …

Herpes simplex virus proteins interact with host (human) proteins and create an environment
conducive for its replication. Genital ulceration due to herpes simplex virus type 2 (HSV-2) …

Over the last thirty years, epidemiologic and molecular studies indicate a strong and
synergist relationship between the dual epidemics of herpes simplex type 2 (HSV-2) and …

A randomized cross-over trial of herpes simplex virus type 2 (HSV-2)-suppressive therapy
(valacyclovir, 500 mg twice daily, or placebo for 8 weeks, a 2-week washout period, then the …

Many studies indicate that herpes simplex virus (HSV) seropositivity increases the risk of
acquiring HIV, with fewer studies also indicating that HSV-2 infection increases the risk of …

Background HIV and herpes simplex virus type 2 (HSV-2) infections cause a substantial
global disease burden and are epidemiologically correlated. Two previous systematic …

Increasing evidence demonstrates a substantial link between the epidemics of sexually
transmitted HIV-1 and herpes simplex virus (HSV)-2 infection. More than 30 epidemiologic …

Background. Few longitudinal studies have described the interactions between reactivation
of herpes simplex virus type 2 (HSV-2) infection (hereafter,“HSV-2 reactivation”) and genital …

Genital ulcers from HSV-2 and syphilis are associated with HIV acquisition. The exact role
for these HIV cofactors is still unknown and exemplified by the failure of HSV suppressive …

Human immunodeficiency virus type 1 (HIV-1)—infected persons have high rates of herpes
simplex virus type 2 (HSV-2) infection, ranging from 50% to 90% in studies of HIV-infected …