Several reviews of coronary physiology have been published in the last decade (Bassenge
1984; Berne and Rubio 1979; Feigl 1983). The purpose of the present review is to provide …

UNDER NORMAL CONDITIONS THE HEART extracts a very large fraction of the oxygen
supplied by the coronary circulation, and consequently there is relatively little reserve …

Coronary microvessels play a pivotal role in determining the supply of oxygen and nutrients
to the myocardium by regulating the coronary flow conductance and substance transport …

Membrane Potential of Coronary Endothelial and Smooth Muscle Cells. In the mammalian
heart the supply of oxygen and energy‐rich substrates through the coronary arterioles is …

The endothelium plays a critical role in the control of vasomotor tone by the release of
vasoactive substances. Because endothelial injury or dysfunction is considered important …

In this review 1 will attempt to analyse our current understanding of the local control of
coronary blood flow. The discussion is organised according to four vasoregulatory situations …

The endothelium has profound potential to modulate coronary arteriolar tone under a variety
of physiological and pathophysiological situations. The endothelium in coronary …

A very schematic summary of possible factors that affect coronary vascular resistance is
illustrated in Fig. 11. These factors are mechanical, myogenic, metabolic, and neural. 64 …

Acute myocardial ischemia, which results from a significant imbalance between myocardial
oxygen demands and myocardial oxygen supply, occurs in as many as six million persons …

There are many mechanisms that contribute to the regulation of coronary blood flow
including vasodilatory metabolites, myogenic regulation, flow-or shear stress-mediated …