[HTML][HTML] A systematic review on the pharmacokinetics of cannabidiol in humans

SA Millar, NL Stone, AS Yates… - Frontiers in …, 2018 - frontiersin.org
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple
conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but …

Examination of a new delivery approach for oral cannabidiol in healthy subjects: a randomized, double-blinded, placebo-controlled pharmacokinetics study

A Patrician, M Versic-Bratincevic, T Mijacika, I Banic… - Advances in …, 2019 - Springer
Introduction Therapeutic effects of cannabidiol (CBD) in specialized populations continue to
emerge. Despite supra-physiological dosing being shown to be tolerable in various …

A phase I, randomized, double-blind, placebo-controlled, single ascending dose, multiple dose, and food effect trial of the safety, tolerability and pharmacokinetics of …

L Taylor, B Gidal, G Blakey, B Tayo, G Morrison - CNS drugs, 2018 - Springer
Background A formal single ascending and multiple dose pharmacokinetic (PK) trial of
cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD …

[HTML][HTML] Dosage, efficacy and safety of cannabidiol administration in adults: a systematic review of human trials

C Larsen, J Shahinas - Journal of clinical medicine research, 2020 - ncbi.nlm.nih.gov
Considering data from in vitro and in vivo studies, cannabidiol (CBD) seems to be a
promising candidate for the treatment of both somatic and psychiatric disorders. The aim of …

Critical aspects affecting cannabidiol oral bioavailability and metabolic elimination, and related clinical implications

E Perucca, M Bialer - CNS drugs, 2020 - Springer
This article provides a critical appraisal of the available evidence concerning clinical
exposure to orally administered cannabidiol (CBD), with special reference to factors …

A systematic review of cannabidiol dosing in clinical populations

SA Millar, NL Stone, ZD Bellman… - British journal of …, 2019 - Wiley Online Library
Aims Cannabidiol (CBD) is a cannabis‐derived medicinal product with potential application
in a wide‐variety of contexts; however, its effective dose in different disease states remains …

[HTML][HTML] Comparison of five oral cannabidiol preparations in adult humans: pharmacokinetics, body composition, and heart rate variability

NNB Williams, TR Ewell, KSS Abbotts, KJ Harms… - Pharmaceuticals, 2021 - mdpi.com
Data supporting the physiological effects of cannabidiol (CBD) ingestion in humans are
conflicting. Differences between CBD preparations and bioavailability may contribute to …

Pharmacokinetic investigation of synthetic cannabidiol oral formulations in healthy volunteers

D Izgelov, E Davidson, D Barasch, A Regev… - European Journal of …, 2020 - Elsevier
Recent advances in the research of medicinal cannabis has placed the non-intoxicating
cannabinoid cannabidiol (CBD) at the front of scientific research. The reasons behind this …

Current status and prospects for cannabidiol preparations as new therapeutic agents

PS Fasinu, S Phillips, MA ElSohly… - … : The Journal of Human …, 2016 - Wiley Online Library
States and the federal government are under growing pressure to legalize the use of
cannabis products for medical purposes in the United States. Sixteen states have legalized …

Cannabidiol for the treatment of brain disorders: therapeutic potential and routes of administration

GTY Yau, W Tai, JC Arnold, HK Chan… - Pharmaceutical …, 2023 - Springer
The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest.
While the mechanism of action of CBD in these conditions is still under investigation, CBD …