[HTML][HTML] A systematic review on the pharmacokinetics of cannabidiol in humans
SA Millar, NL Stone, AS Yates… - Frontiers in …, 2018 - frontiersin.org
Background: Cannabidiol is being pursued as a therapeutic treatment for multiple
conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but …
conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but …
Examination of a new delivery approach for oral cannabidiol in healthy subjects: a randomized, double-blinded, placebo-controlled pharmacokinetics study
A Patrician, M Versic-Bratincevic, T Mijacika, I Banic… - Advances in …, 2019 - Springer
Introduction Therapeutic effects of cannabidiol (CBD) in specialized populations continue to
emerge. Despite supra-physiological dosing being shown to be tolerable in various …
emerge. Despite supra-physiological dosing being shown to be tolerable in various …
A phase I, randomized, double-blind, placebo-controlled, single ascending dose, multiple dose, and food effect trial of the safety, tolerability and pharmacokinetics of …
L Taylor, B Gidal, G Blakey, B Tayo, G Morrison - CNS drugs, 2018 - Springer
Background A formal single ascending and multiple dose pharmacokinetic (PK) trial of
cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD …
cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD …
[HTML][HTML] Dosage, efficacy and safety of cannabidiol administration in adults: a systematic review of human trials
C Larsen, J Shahinas - Journal of clinical medicine research, 2020 - ncbi.nlm.nih.gov
Considering data from in vitro and in vivo studies, cannabidiol (CBD) seems to be a
promising candidate for the treatment of both somatic and psychiatric disorders. The aim of …
promising candidate for the treatment of both somatic and psychiatric disorders. The aim of …
Critical aspects affecting cannabidiol oral bioavailability and metabolic elimination, and related clinical implications
E Perucca, M Bialer - CNS drugs, 2020 - Springer
This article provides a critical appraisal of the available evidence concerning clinical
exposure to orally administered cannabidiol (CBD), with special reference to factors …
exposure to orally administered cannabidiol (CBD), with special reference to factors …
A systematic review of cannabidiol dosing in clinical populations
SA Millar, NL Stone, ZD Bellman… - British journal of …, 2019 - Wiley Online Library
Aims Cannabidiol (CBD) is a cannabis‐derived medicinal product with potential application
in a wide‐variety of contexts; however, its effective dose in different disease states remains …
in a wide‐variety of contexts; however, its effective dose in different disease states remains …
[HTML][HTML] Comparison of five oral cannabidiol preparations in adult humans: pharmacokinetics, body composition, and heart rate variability
NNB Williams, TR Ewell, KSS Abbotts, KJ Harms… - Pharmaceuticals, 2021 - mdpi.com
Data supporting the physiological effects of cannabidiol (CBD) ingestion in humans are
conflicting. Differences between CBD preparations and bioavailability may contribute to …
conflicting. Differences between CBD preparations and bioavailability may contribute to …
Pharmacokinetic investigation of synthetic cannabidiol oral formulations in healthy volunteers
D Izgelov, E Davidson, D Barasch, A Regev… - European Journal of …, 2020 - Elsevier
Recent advances in the research of medicinal cannabis has placed the non-intoxicating
cannabinoid cannabidiol (CBD) at the front of scientific research. The reasons behind this …
cannabinoid cannabidiol (CBD) at the front of scientific research. The reasons behind this …
Current status and prospects for cannabidiol preparations as new therapeutic agents
PS Fasinu, S Phillips, MA ElSohly… - … : The Journal of Human …, 2016 - Wiley Online Library
States and the federal government are under growing pressure to legalize the use of
cannabis products for medical purposes in the United States. Sixteen states have legalized …
cannabis products for medical purposes in the United States. Sixteen states have legalized …
Cannabidiol for the treatment of brain disorders: therapeutic potential and routes of administration
The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest.
While the mechanism of action of CBD in these conditions is still under investigation, CBD …
While the mechanism of action of CBD in these conditions is still under investigation, CBD …