Autophagy is a fundamental homeostatic process in which certain cellular components are
ingested by double-membrane autophagosomes and then degraded to create energy or to …

Reactive oxygen species (ROS) are important in regulating normal cellular processes, but
deregulated ROS contribute to the development of various human diseases including …

Redox signaling plays important roles in the regulation of cell death and survival in
response to cancer therapy. Autophagy and apoptosis are discrete cellular processes …

Reactive oxygen species (ROS), products of normal cellular metabolism, play an important
role in signal transduction. Autophagy is an intracellular degradation process in response to …

Autophagy is a catabolic process involving lysosomal turnover of proteins and organelles for
maintenance of cellular homeostasis and mitigation of metabolic stress. Autophagy defects …

Cancer formation is a highly regulated and complex process, largely dependent on its
microenvironment. This complexity highlights the need for developing novel target-based …

Aging and cancer are highly related biological phenomena. Cellular processes that
underpin several malignant phenotypic traits, including DNA damage responses, oxidative …

Reactive oxygen species (ROS) have been identified as signaling molecules in various
pathways regulating both cell survival and cell death. Autophagy, a self-digestion process …

Two prominent features of tumors that contribute to oncogenic survival signaling are redox
disruption, or oxidative stress phenotype, and high autophagy signaling, making both …

Aberrant cell death signaling and oxidative stress are implicated in myriad of human
pathological states such as neurodegenerative, cardiovascular, metabolic and liver …