High levels of CC‐chemokine expression and downregulated levels of CCR5 during HIV‐1/HTLV‐1 and HIV‐1/HTLV‐2 coinfections

Z Oo, CS Barrios, L Castillo… - Journal of Medical …, 2015 - Wiley Online Library
The human T‐cell lymphotropic virus type 1 (HTLV‐1) and HTLV‐2 are common
copathogens among Human Immunodeficiency Virus (HIV)‐infected individuals. HTLV‐2 …

Human T cell leukaemia virus type 2 tax protein mediates CC-chemokine expression in peripheral blood mononuclear cells via the nuclear factor kappa B canonical …

CS Barrios, L Castillo, H Zhi, CZ Giam… - Clinical & …, 2014 - academic.oup.com
Retroviral co-infections with human immunodeficiency virus type-1 (HIV-1) and human T cell
leukaemia virus type 1 (HTLV-1) or type 2 (HTLV-2) are prevalent in many areas worldwide …

Postgenomic up-regulation of CCL3L1 expression in HTLV-2–infected persons curtails HIV-1 replication

E Pilotti, L Elviri, E Vicenzi, U Bertazzoni, MC Re… - Blood, 2007 - ashpublications.org
Leukocytes of persons coinfected with HTLV-2 and HIV-1 secrete chemokines that prevent
CCR5-dependent (R5) HIV-1 infection of CD4+ T cells and macrophages, with HTLV-2 …

Induction of CC-chemokines with antiviral function in macrophages by the human T lymphotropic virus type 2 transactivating protein, Tax2

G Balistrieri, CS Barrios, L Castillo… - Viral …, 2013 - liebertpub.com
Recent data provide evidence that co-infection with human immunodeficiency virus type 1
(HIV-1) and human T lymphotropic virus type 2 (HTLV-2) delays progression to AIDS …

[HTML][HTML] People with HIV have higher percentages of circulating CCR5+ CD8+ T cells and lower percentages of CCR5+ regulatory T cells

LE van Eekeren, V Matzaraki, Z Zhang… - Scientific Reports, 2022 - nature.com
CCR5 is the main HIV co-receptor. We aimed to (1) compare CCR5 expression on immune
cells between people living with HIV (PLHIV) using combination antiretroviral therapy …

The CCL2/CCR2 axis in the pathogenesis of HIV-1 infection: a new cellular target for therapy?

D Angela Covino, M Sabbatucci… - Current drug targets, 2016 - ingentaconnect.com
The identification of chemokine receptors as necessary co-receptors for HIV entry into target
cells represented a breakthrough in the understanding of the pathogenesis of this viral …

[HTML][HTML] Increased plasma levels of the TH2 chemokine CCL18 associated with low CD4+ T cell counts in HIV-1-infected patients with a suppressed viral load

P Malhotra, P Haslett, B Sherry, DH Shepp, P Barber… - Scientific reports, 2019 - nature.com
The chemokine (CC motif) chemokine ligand 18 (CCL18) is a structural homolog of CCL3
primarily produced by monocyte-derived cells with an M2 phenotype. Elevated levels of …

[HTML][HTML] Biomarkers of HIV susceptibility and disease progression

V Pirrone, J Mell, B Janto, B Wigdahl - EBioMedicine, 2014 - thelancet.com
Both host and viral factors are associated with HIV-1 susceptibility and disease progression.
Host factors can typically be divided into three categories (Chatterjee, 2010): 1) genes …

Changes in CCR5 and CXCR4 expression and β-chemokine production in HIV-1-infected patients treated with highly active antiretroviral therapy

M Pierdominici, A Giovannetti, F Ensoli… - JAIDS Journal of …, 2002 - journals.lww.com
The effect of highly active antiretroviral therapy (HAART) on the expression of CCR5 and
CXCR4 HIV coreceptors and the production of the [beta]-chemokines regulated upon …

CCR5 Expression Is Reduced in Lymph Nodes of HIV Type 1–Infected Women, Compared With Men, But Does Not Mediate Sex-Based Differences in Viral Loads

AL Meditz, JM Folkvord, NH Lyle… - The Journal of …, 2014 - academic.oup.com
Background. Human immunodeficiency virus type 1 (HIV-1)–infected women have lower
viral loads than men but similar rates of disease progression. We hypothesized that sex …