Fibrillar collagens are prominent extracellular matrix (ECM) components, and their topology
changes have been shown to be associated with the progression of a wide range of …

Quantification of fibrillar collagen organization has given new insight into the possible role of
collagen topology in many diseases and has also identified candidate image-based bio …

Recent evidence has implicated collagen, particularly fibrillar collagen, in a number of
diseases ranging from osteogenesis imperfecta and asthma to breast and ovarian cancer. A …

The role of fibrillar collagen in the tissue microenvironment is critical in disease contexts
ranging from cancers to chronic inflammations, as evidenced by many studies. Quantifying …

Collagen fibers in biological tissues have a complex 3D organization containing rich
information linked to tissue mechanical properties and are affected by mutations that lead to …

Metastatic cancers aggressively reorganize collagen in their microenvironment. For
example, radially orientated collagen fibers have been observed surrounding tumor cell …

Collagen is the most abundant protein in mammals; it exhibits a hierarchical organization
and provides structural support to a wide range of soft tissues, including blood vessels. The …

Recent research has highlighted the importance of key tumor microenvironment features,
notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and …

In the version of this article initially published, the authors acknowledged the research
support from the National Institutes of Health (U01-CA177799) and the National Science …

The importance of fibrillar collagen topology and organization in disease progression and
prognostication in different types of cancer has been characterized extensively in many …