Box H/ACA ribonucleoproteins (RNPs), each consisting of one unique guide RNA and 4
common core proteins, constitute a family of complex enzymes that catalyze, in an RNA …

During the biogenesis of eukaryotic ribosomal RNA (rRNA) and spliceosomal small nuclear
RNA (snRNA), uridines at specific sites are converted to pseudouridines by H/ACA …

Pseudouridine, the most abundant modified nucleoside in RNA, is synthesized by
posttranscriptional isomerization of uridines. In eukaryotic RNAs, site-specific synthesis of …

Abstract H/ACA ribonucleoproteins (H/ACA RNPs) are responsible for introducing many
pseudouridines into RNAs, but are also involved in other cellular functions. Utilizing a …

Pseudouridine is the most abundant post-transcriptionally modified nucleotide in various
stable RNAs of all organisms. Pseudouridine is derived from uridine via base-specific …

Pseudouridine (Ψ) is the most abundant posttranscriptional modification in noncoding
RNAs. Pseudouridines are often clustered in important regions of rRNAs (ribosomal RNAs) …

Box H/ACA RNAs are a group of small RNAs found in abundance in eukaryotes (as well as
in archaea). Although their sequences differ, eukaryotic box H/ACA RNAs all share the same …

Pseudouridine (Ψ) are frequently modified residues in RNA. In Eukarya, their formation is
catalyzed by enzymes or by ribonucleoprotein complexes (RNPs) containing H/ACA …

Abstract The H/ACA ribonucleoproteins (RNPs) are known as one of the two major classes
of small nucleolar RNPs. They predominantly guide the site-directed pseudouridylation of …

A large number of box H/ACA RNAs have been identified in human cells, and have been
predicted to account for nearly all pseudouridylation sites in human rRNAs. However, the …