Inhibitors of angiogenesis in cancer therapy–synthesis and biological activity

M Gensicka, A Glowacka, K Dzierzbicka… - Current Medicinal …, 2015 - ingentaconnect.com
Angiogenesis is the process of formation of new capillaries from preexisting blood vessels.
Angiogenesis is involved in normal physiological processes, and plays an important role in …

Recent advances in antiangiogenic agents with VEGFR as target

J Zhang, Y Shan, X Pan, L He - Mini reviews in medicinal …, 2011 - ingentaconnect.com
Angiogenesis is required for invasive tumor growth and metastasis and constitutes an
important point in the control of cancer progression. Its inhibition may be a valuable …

Novel Products as Promising Therapeutic Agents for Angiogenesis Inhibition.

S Sultana, MNU SN, A Zafar - Current Drug Delivery, 2024 - europepmc.org
Objective Angiogenesis is the process of forming new blood vessels from pre-existing
vessels and occurs during development, wound healing, and tumor growth. In this review …

Mechanisms of anti-angiogenic therapy

R Pons-Cursach, O Casanovas - Tumor Angiogenesis: A Key Target for …, 2019 - Springer
Angiogenesis inhibition is a promising approach to fight cancer. This strategy offers some
advantages in comparison with conventional drugs, such as the inhibition of single vessels …

Angiogenesis and angiogenesis inhibitors: a new potential anticancer therapeutic strategy

G Ranieri, G Gasparini - Current Drug Targets-Immune …, 2001 - ingentaconnect.com
Tumor cells cannot grow as a mass above 2 to 3 mm3 because diffusion is insufficient for
oxygen and glucose requirements, unless the tumor induces a blood supply. This …

[HTML][HTML] Vascular endothelial growth factor receptor (VEGFR-2)/KDR inhibitors: medicinal chemistry perspective

SJ Modi, VM Kulkarni - Medicine in Drug Discovery, 2019 - Elsevier
New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

Use of angiogenesis inhibitors in tumour treatment

J Fayette, JC Soria, JP Armand - European Journal of Cancer, 2005 - Elsevier
Advances in molecular biology have permitted the characterisation of mechanisms
underlying angiogenesis. Angiogenesis is a crucial process in tumour pathogenesis as it …

Inhibition of angiogenesis

M Lagos-Quintana, S Rafii, SH Chavala - US Patent 9,179,654, 2015 - Google Patents
BACKGROUND Angiogenesis, the formation of new blood vessels, occurs in the healthy
body for healing wounds, for restoring blood flow to tissues after injury, and in certain other …

New developments in anti-angiogenic therapy of cancer, review and update

S Ghasemali, S Farajnia, A Barzegar… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
Background: Angiogenesis is one of the critical physiological processes, by which the new
blood vessels are generated from the pre-existing vessels in the early stage of …

[HTML][HTML] New advances in the research of clinical treatment and novel anticancer agents in tumor angiogenesis

X Li, J Zhou, X Wang, C Li, Z Ma, Q Wan… - Biomedicine & …, 2023 - Elsevier
In 1971, Folkman proposed that tumors could be limited to very small sizes by blocking
angiogenesis. Angiogenesis is the generation of new blood vessels from pre-existing …