Molecular, Genetic Susceptibility and Immunotherapy of Melanoma

PV Shenoy, R Nag, KK Kolathur, Y Malik, SM Varanasi… - 2023 - preprints.org
Skin cancer is a prevalent and heterogenous disease with several subtypes, such as
melanoma, basal cell carcinoma, and squamous cell carcinoma. Among them, melanoma is …

Genetics and genomics of melanoma: Current progress and future directions

C Quek - Genes, 2023 - mdpi.com
Melanoma is a form of skin cancer that develops in the skin's pigment cells, known as
melanocytes, and can spread via blood and the lymphatic system to nearby tissues or …

The impact of melanoma genetics on treatment response and resistance in clinical and experimental studies

M Kunz, M Hölzel - Cancer and Metastasis Reviews, 2017 - Springer
Recent attempts to characterize the melanoma mutational landscape using high-throughput
sequencing technologies have identified new genes and pathways involved in the …

Individualized treatment strategy for cutaneous melanoma: Where are we now and where are we going?

H Zeng, F Liu, H Zhou, C Zeng - Frontiers in oncology, 2021 - frontiersin.org
In the past several decades, innovative research in cancer biology and immunology has
contributed to novel therapeutics, such as targeted therapy and immunotherapy, which have …

The genomic landscape of melanoma and its therapeutic implications

TT Yang, S Yu, CLK Ke, ST Cheng - Genes, 2023 - mdpi.com
Melanoma is one of the most aggressive malignancies of the skin. The genetic composition
of melanoma is complex and varies among different subtypes. With the aid of recent …

[PDF][PDF] Cutaneous melanoma classification: the importance of high-throughput genomic technologies

C Scatena, D Murtas, S Tomei - Frontiers in oncology, 2021 - frontiersin.org
Cutaneous melanoma is an aggressive tumor responsible for 90% of mortality related to skin
cancer. In the recent years, the discovery of driving mutations in melanoma has led to better …

Melanoma genetics: the other side

S Bis, H Tsao - Clinics in dermatology, 2013 - Elsevier
Although melanoma has traditionally been regarded as a uniformly fatal malignancy,
personalized treatment of this cancer relies on the recognition of its genetic heterogeneity …

Molecular pathology of skin melanoma: epidemiology, differential diagnostics, prognosis and therapy prediction

J Tímár, A Ladányi - International journal of molecular sciences, 2022 - mdpi.com
Similar to other malignancies, TCGA network efforts identified the detailed genomic picture
of skin melanoma, laying down the basis of molecular classification. On the other hand …

Genomic and transcriptomic underpinnings of melanoma genesis, progression, and metastasis

OS Cherepakhin, ZB Argenyi, AS Moshiri - Cancers, 2021 - mdpi.com
Simple Summary Melanoma is a skin cancer with a high mortality and a dramatically rising
presence worldwide. Recent research has shed new light on the genetic events that …

Molecular characterisation of cutaneous melanoma: creating a framework for targeted and immune therapies

S Rajkumar, IR Watson - British journal of cancer, 2016 - nature.com
Large-scale genomic analyses of cutaneous melanoma have revealed insights into the
aetiology and heterogeneity of this disease, as well as opportunities to further personalise …