Patient-derived exosomes facilitate therapeutic targeting of oncogenic MET in advanced gastric cancer

S Hyung, J Ko, YJ Heo, SM Blum, ST Kim, SH Park… - Science …, 2023 - science.org
Gastric cancer (GC) with peritoneal metastases and malignant ascites continues to have
poor prognosis. Exosomes mediate intercellular communication during cancer progression …

Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer

Y Hu, C Qi, X Liu, C Zhang, J Gao, Y Wu, J Yang… - Cancer Letters, 2019 - Elsevier
Peritoneal dissemination (PD) is the most frequent metastasis with poor prognosis in
patients with advanced gastric cancer (GC). However, the molecular mechanisms of PD …

The distinct roles of exosomes in tumor-stroma crosstalk within gastric tumor microenvironment

H Zhang, M Yang, X Wu, Q Li, X Li, Y Zhao, F Du… - Pharmacological …, 2021 - Elsevier
Gastric cancer (GC) development is a complex process displaying polytropic cell and
molecular landscape within gastric tumor microenvironment (TME). Stromal cells in TME …

Emerging roles of mesenchymal stem cell-derived exosomes in gastrointestinal cancers

N Wang, B Pei, X Yuan, C Yi… - … in Bioengineering and …, 2022 - frontiersin.org
Gastrointestinal tumours are the most common solid tumours, with a poor prognosis and
remain a major challenge in cancer treatment. Mesenchymal stem cells (MSC) are …

Exosomes in the tumor microenvironment: From biology to clinical applications

VR da Costa, RP Araldi, H Vigerelli, F D'Ámelio… - Cells, 2021 - mdpi.com
Cancer is one of the most important health problems and the second leading cause of death
worldwide. Despite the advances in oncology, cancer heterogeneity remains challenging to …

Exosomes promote pre-metastatic niche formation in gastric cancer

J Gao, S Li, Q Xu, X Zhang, M Huang, X Dai… - Frontiers in …, 2021 - frontiersin.org
Gastric cancer has a high rate of metastasis, during which pre-metastatic niches (PMN)
provide a supportive environment for the upcoming tumor cells. Exosomes are bilayer …

Gastric cancer‐derived exosomes promote peritoneal metastasis by destroying the mesothelial barrier

G Deng, J Qu, Y Zhang, X Che, Y Cheng, Y Fan… - Febs …, 2017 - Wiley Online Library
An intact mesothelium serves as a protective barrier to inhibit peritoneal carcinomatosis.
Cancer‐derived exosomes can mediate directional tumor metastasis; however, little is …

Exosomes in cancer development and clinical applications

YL Tai, KC Chen, JT Hsieh, TL Shen - Cancer science, 2018 - Wiley Online Library
Exosomes participate in cancer progression and metastasis by transferring bioactive
molecules between cancer and various cells in the local and distant microenvironments …

Roles of mesenchymal stem cell‐derived exosomes in cancer development and targeted therapy

Z Sun, J Zhang, J Li, M Li, J Ge, P Wu… - Stem Cells …, 2021 - Wiley Online Library
Exosomes have emerged as a new drug delivery system. In particular, exosomes derived
from mesenchymal stem cells (MSCs) have been extensively studied because of their tumor …

Delivery of engineered primary tumor-derived exosomes effectively suppressed the colorectal cancer chemoresistance and liver metastasis

C Huang, Y Zhou, X Feng, J Wang, Y Li, X Yao - ACS nano, 2023 - ACS Publications
Liver metastasis is one of the major causes of colorectal cancer (CRC)-related morbidity and
mortality. Delivering small interfering RNAs (siRNAs) or noncoding RNAs has been reported …