Proliferation and activation of microglia in the brain, concentrated around amyloid plaques,
is a prominent feature of Alzheimer's disease (AD). Human genetics data point to a key role …

Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's
disease (AD). Thus far, microglia have rather been known as modulator of …

The identification of microglia-associated, neurological disease-causing mutations in
patients, combined with studies in mouse models has highlighted microglia, the brain's …

Alzheimer's disease (AD) is characterized by extracellular aggregates of amyloid β peptides,
intraneuronal tau aggregates, and neuronal death. This pathology triggers activation of …

Alzheimer's disease (AD) is a neurodegenerative disorder that usually develops slowly and
progressively worsens over time. Although there has been increasing research interest in …

Research into the function of microglia has dramatically accelerated during the last few
years, largely due to recent genetic findings implicating microglia in virtually every …

Microglia are resident immune cells in the central nervous system (CNS) that originate from
myeloid progenitor cells in the embryonic yolk sac and are maintained independently of …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting elderly
people worldwide, which is mainly characterized by cerebral amyloid-beta (Aβ) plaque …

Advances in human genetics have implicated a growing number of genes in
neurodegenerative diseases, providing insight into pathological processes. For Alzheimer …