Abstract Changes in extracellular osmolality have been shown to alter gene expression
patterns and metabolic activity of various cell types, including chondrocytes. However …

Articular cartilage protects and lubricates joints for smooth motion and transmission of loads.
Owing to its high water content, chondrocytes within the cartilage are exposed to high levels …

In the absence of active volume regulation processes, cell volume is inversely proportional
to osmolarity, as predicted by the Boyle Van't Hoff relation. In this study, we tested the …

The biophysical features of a cell can provide global insights into diverse molecular
changes, especially in processes like the dedifferentiation of chondrocytes. Key biophysical …

While chondrocytes in articular cartilage experience dynamic stimuli from joint loading
activities, few studies have examined the effects of dynamic osmotic loading on their …

Articular chondrocytes experience changes to matrix hydration during both physiological
(static load) and pathophysiological (osteoarthrosis, OA) conditions. Such changes should …

Articular chondrocytes are exposed to a unique osmotic environment, which varies
throughout the depth of cartilage, and in response to mechanical loading or pathological …

Articular chondrocytes in vivo are exposed to a changing osmotic environment under both
physiological (static load) and pathological (osteoarthritis) conditions. Such changes to …

Metabolism of the matrix by chondrocytes is sensitive to alterations in cell volume that occur,
for example, during static loading and osteoarthritis. The ability of chondrocytes to respond …

Articular cartilage has distinct histological depth zones. In each zone, chondrocytes are
subject to different hydrostatic (HP) and osmotic pressure (OP) due to weight-bearing and …