[HTML][HTML] Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes

J Irianto, J Swift, RP Martins, GD McPhail, MM Knight… - Biophysical journal, 2013 - cell.com
Abstract Changes in extracellular osmolality have been shown to alter gene expression
patterns and metabolic activity of various cell types, including chondrocytes. However …

Hydrostatic pressure prevents chondrocyte differentiation through heterochromatin remodeling

K Maki, MM Nava, C Villeneuve… - Journal of cell …, 2021 - journals.biologists.com
Articular cartilage protects and lubricates joints for smooth motion and transmission of loads.
Owing to its high water content, chondrocytes within the cartilage are exposed to high levels …

Nonlinear osmotic properties of the cell nucleus

JD Finan, KJ Chalut, A Wax, F Guilak - Annals of biomedical engineering, 2009 - Springer
In the absence of active volume regulation processes, cell volume is inversely proportional
to osmolarity, as predicted by the Boyle Van't Hoff relation. In this study, we tested the …

[HTML][HTML] Dedifferentiation alters chondrocyte nuclear mechanics during in vitro culture and expansion

S Ghosh, AK Scott, B Seelbinder, JE Barthold… - Biophysical …, 2022 - cell.com
The biophysical features of a cell can provide global insights into diverse molecular
changes, especially in processes like the dedifferentiation of chondrocytes. Key biophysical …

Chondrocyte intracellular calcium, cytoskeletal organization, and gene expression responses to dynamic osmotic loading

PG Chao, AC West, CT Hung - American Journal of …, 2006 - journals.physiology.org
While chondrocytes in articular cartilage experience dynamic stimuli from joint loading
activities, few studies have examined the effects of dynamic osmotic loading on their …

The osmotic sensitivity of isolated and in situ bovine articular chondrocytes

PG Bush, AC Hall - Journal of Orthopaedic Research, 2001 - Wiley Online Library
Articular chondrocytes experience changes to matrix hydration during both physiological
(static load) and pathophysiological (osteoarthrosis, OA) conditions. Such changes should …

Adaptation of articular chondrocytes to changes in osmolality

B Hopewell, JPG Urban - Biorheology, 2003 - content.iospress.com
Articular chondrocytes are exposed to a unique osmotic environment, which varies
throughout the depth of cartilage, and in response to mechanical loading or pathological …

Regulatory volume decrease (RVD) by isolated and in situ bovine articular chondrocytes

PG Bush, AC Hall - Journal of cellular physiology, 2001 - Wiley Online Library
Articular chondrocytes in vivo are exposed to a changing osmotic environment under both
physiological (static load) and pathological (osteoarthritis) conditions. Such changes to …

[HTML][HTML] Chondrocyte de-differentiation: Biophysical cues to nuclear alterations

NA Al-Maslamani, R Oldershaw, S Tew, J Curran… - Cells, 2022 - mdpi.com
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI
a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro. The …

Regulatory volume increase (RVI) by in situ and isolated bovine articular chondrocytes

MJP Kerrigan, CSV Hook, A Qusous… - Journal of cellular …, 2006 - Wiley Online Library
Metabolism of the matrix by chondrocytes is sensitive to alterations in cell volume that occur,
for example, during static loading and osteoarthritis. The ability of chondrocytes to respond …