The 26S proteasome is a large,∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex
that serves as the degrading arm of the ubiquitin system, which is the major pathway for …

The ubiquitin proteasome pathway is responsible for most of the protein degradation in
mammalian cells. Rates of degradation by this pathway have generally been assumed to be …

The regulated degradation of proteins within eukaryotes and bacterial cells is catalyzed
primarily by large multimeric proteases in ATP-dependent manner. In eukaryotes, the 26 S …

The 26S proteasome is a large multiprotein complex involved in the regulated degradation
of ubiquitinated proteins in the cell. The 26S proteasome has been shown to control an …

▪ Abstract In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …

The 26S proteasome constitutes the central proteolytic machinery of the highly conserved
ubiquitin/proteasome system, the cell's major tool for extralysosomal protein degradation …

As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal
proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The …

The 20S proteasome, an approximately 700-kDa complex of 28 protein subunits, performs
most of the proteolysis that takes place in the cytosol and nucleus of eukaryotic cells. As …

For many years, the ubiquitin-26S proteasome degradation pathway was considered the
primary route for proteasomal degradation. However, it is now becoming clear that proteins …

Eukaryotic proteasomes are unusually large protein complexes with characteristic sets of
subunits and have been classified into two isoforms with apparent sedimentation coefficients …