The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA
accumulation in cultured liver cells, but its potential as a target for antiviral intervention has …

MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression.
MicroRNA 122 (miR-122) is specifically expressed and highly abundant in the human liver …

Several microRNAs (miRNAs), including liver-specific miR-122, have been implicated in the
control of hepatitis C virus (HCV) RNA replication and its response to interferon (IFN) in …

Hepatitis C virus subverts liver-specific microRNA, miR-122, to upregulate viral RNA
abundance in both infected cultured cells and in the liver of infected chimpanzees. These …

MicroRNA-122 (miR-122) is believed to stimulate hepatitis C virus (HCV) replication through
interaction with two adjacent sites downstream of stem loop I (SLI) within the HCV 5 …

Background The stability and propagation of hepatitis C virus (HCV) is dependent on a
functional interaction between the HCV genome and liver-expressed microRNA-122 (miR …

Hepatitis C virus (HCV) is a serious global health problem and establishes chronic infection
in a significant number of infected humans worldwide. Interferon (IFN) and IFN-stimulated …

Hepatitis C virus (HCV) is one of the most common etiologic agents of chronic liver diseases,
including liver cirrhosis and hepatocellular carcinoma. In addition, HCV infection is often …

Abstract microRNAs (miRNAs) are small RNAs that in general down-regulate the
intracellular abundance and translation of targetmRNAs. We noted that sequestration of liver …

The abundant, liver-specific microRNA miR-122 forms extensive base-pairing interactions
with the 5′ noncoding region of the hepatitis C virus (HCV) RNA genome, protecting the …