Wiping out CGRP: potential cardiovascular risks
A MaassenVanDenBrink, J Meijer, CM Villalón… - Trends in …, 2016 - cell.com
Migraine is a common episodic neurovascular brain disorder associated with increased risk
of cardio-and cerebrovascular ischemia. Migraine headache is likely caused by activation of …
of cardio-and cerebrovascular ischemia. Migraine headache is likely caused by activation of …
CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP?
V Favoni, L Giani, L Al-Hassany, GM Asioli… - The journal of headache …, 2019 - Springer
Calcitonin gene-related peptide (CGRP) is a neuropeptide with a pivotal role in the
pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with …
pathophysiology of migraine. Blockade of CGRP is a new therapeutic target for patients with …
Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice
IA Mulder, M Li, T de Vries, T Qin… - Annals of …, 2020 - Wiley Online Library
Objective Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging
treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue …
treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue …
[HTML][HTML] CGRP and migraine: from bench to bedside
L Edvinsson - Revue neurologique, 2021 - Elsevier
Migraine treatment has reached a new era with the development of drugs that target the
trigeminal neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. The CGRP …
trigeminal neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. The CGRP …
CGRP blockers in migraine therapy: where do they act?
L Edvinsson - British journal of pharmacology, 2008 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) is expressed throughout the CNS and peripheral
nervous system, consistent with control of vasodilatation, nociception, motor function …
nervous system, consistent with control of vasodilatation, nociception, motor function …
CGRP inhibitors for migraine prophylaxis: a safety review
E Rivera-Mancilla, CM Villalón… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Since calcitonin gene-related peptide (CGRP) plays an important role in the
pathophysiology of migraine via the activation of the trigeminovascular system, the newest …
pathophysiology of migraine via the activation of the trigeminovascular system, the newest …
CGRP antagonists: unravelling the role of CGRP in migraine
H Doods, K Arndt, K Rudolf, S Just - Trends in pharmacological sciences, 2007 - cell.com
Migraine is a complex, debilitating neurovascular disorder. Although knowledge on the main
molecular players is still incomplete, recent preclinical and clinical findings indicate that …
molecular players is still incomplete, recent preclinical and clinical findings indicate that …
Blocking CGRP in migraine patients–a review of pros and cons
M Deen, E Correnti, K Kamm, T Kelderman… - The journal of headache …, 2017 - Springer
Migraine is the most prevalent neurological disorder worldwide and it has immense
socioeconomic impact. Currently, preventative treatment options for migraine include drugs …
socioeconomic impact. Currently, preventative treatment options for migraine include drugs …
CGRP monoclonal antibodies for migraine: rationale and progress
Calcitonin gene-related peptide (CGRP), a neuropeptide abundant in the trigeminal system
and widely expressed in both the peripheral and central nervous systems, has recently …
and widely expressed in both the peripheral and central nervous systems, has recently …
Inhibition of calcitonin gene‐related peptide function: a promising strategy for treating migraine
PL Durham - Headache: The Journal of Head and Face Pain, 2008 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is implicated in the underlying
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …