The gut microbiome: Relationships with disease and opportunities for therapy

J Durack, SV Lynch - Journal of experimental medicine, 2019 - rupress.org
Over the past decade, our view of human-associated microbes has expanded beyond that of
a few species toward an appreciation of the diverse and niche-specialized microbial …

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota

CT Peterson, V Sharma, L Elmén… - Clinical & Experimental …, 2015 - academic.oup.com
The distal gut harbours∼ 1013 bacteria, representing the most densely populated
ecosystem known. The functional diversity expressed by these communities is enormous …

Bugging inflammation: role of the gut microbiota

S Shen, CHY Wong - Clinical & translational immunology, 2016 - Wiley Online Library
The advent of vaccination and improved hygiene have eliminated many of the deadly
infectious pathogens in developed nations. However, the incidences of inflammatory …

Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes

T Clavel, JC Gomes‐Neto, I Lagkouvardos… - Immunological …, 2017 - Wiley Online Library
The community of microorganisms in the mammalian gastrointestinal tract, referred to as the
gut microbiota, influences host physiology and immunity. The last decade of microbiome …

Microbes in gastrointestinal health and disease

AS Neish - Gastroenterology, 2009 - Elsevier
Most, if not all, animals coexist with a complement of prokaryotic symbionts that confer a
variety of physiologic benefits. In humans, the interaction between animal and bacterial cells …

[HTML][HTML] Exploring gut microbes in human health and disease: pushing the envelope

J Sun, EB Chang - Genes & diseases, 2014 - Elsevier
Humans have coevolved with their microbes over thousands of years, but this relationship, is
now being dramatically affected by shifts in the collective human microbiome resulting from …

Novel perspectives on therapeutic modulation of the gut microbiota

JL McCarville, A Caminero… - Therapeutic advances in …, 2016 - journals.sagepub.com
The gut microbiota contributes to the maintenance of health and, when disrupted, may drive
gastrointestinal and extragastrointestinal disease. This can occur through direct pathways …

The human gut microbiome: from association to modulation

TSB Schmidt, J Raes, P Bork - Cell, 2018 - cell.com
Our understanding of the human gut microbiome continues to evolve at a rapid pace, but
practical application of thisknowledge is still in its infancy. This review discusses the type of …

Host–microbe interactions shaping the gastrointestinal environment

GE Kaiko, TS Stappenbeck - Trends in immunology, 2014 - cell.com
Tremendous advances have been made in mapping the complexity of the human gut
microbiota in both health and disease states. These analyses have revealed that, rather than …

Gut microbes as future therapeutics in treating inflammatory and infectious diseases: lessons from recent findings

S Mukherjee, N Joardar, S Sengupta… - The Journal of nutritional …, 2018 - Elsevier
The human gut microbiota has been the interest of extensive research in recent years and
our knowledge on using the potential capacity of these microbes are growing rapidly …