Nitrogen metabolism of Mycobacterium tuberculosis (Mtb) is crucial for the survival of this
important pathogen in its primary human host cell, the macrophage, but little is known about …

Several major pathogens, including Mycobacterium tuberculosis, parasitize host cells and
exploit host-derived nutrients to sustain their own metabolism. Although the carbon sources …

Bacterial metabolism is fundamental to survival and pathogenesis. We explore how
Mycobacterium tuberculosis utilises amino acids as nitrogen sources, using a combination …

In high enough concentrations, such as produced by inducible nitric oxide synthase (iNOS),
reactive nitrogen species (RNS) can kill Mycobacterium tuberculosis (Mtb). Lesional …

Urease represents a critical virulence factor for some bacterial species through its alkalizing
effect, which helps neutralize the acidic microenvironment of the pathogen. In addition …

A key component to the success of M ycobacterium tuberculosis as a pathogen is the ability
to sense and adapt metabolically to the diverse range of conditions encountered in vivo …

Metabolic adaptation to the host environment is a defining feature of the pathogenicity of
Mycobacterium tuberculosis (Mtb), but we lack biochemical knowledge of its metabolic …

The mechanisms whereby Mycobacterium tuberculosis (Mtb) rewires the host metabolism in
vivo are surprisingly unexplored. Here, we used three high-resolution mass spectrometry …

The immune response to Mycobacterium tuberculosis (Mtb) includes expression of nitric
oxide (NO) synthase (NOS) 2, whose products can kill Mtb in vitro with a molar potency …

Mycobacterium tuberculosis is the cause of tuberculosis (TB), a disease which continues to
overwhelm health systems in endemic regions despite the existence of effective combination …