Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …

This review focuses on the structural models for cytochrome P450, which are improving our
knowledge and understanding of the P450 catalytic cycle, and the way in which substrates …

The protein database has> 450 entries with P450 in the title and of these there are
approximately 54 unique structures. Although this sample of unique structures is small …

This book covers the relevant aspects of cytochromes P450 for understanding their structure,
function and mechanisms of action, such as physicochemical characterization methods …

P450 enzymes have evolved into a large superfamily that displays great diversity in
substrate and product specificities by fixing the natural amino acid substitutions with high …

Abstract Cytochromes P450 (P450s) are a large superfamily of heme-containing
monooxygenases. P450s are found in all Kingdoms of life and exhibit incredible diversity …

The significance of cytochrome P450 catalyzed reactions has now been recognized for more
than 30 years [1] as one of nature's most common and sophisticated methods to oxidize …

Cytochrome P450 isoenzymes are pivotal in drug clearance. Part 1 of this two-part review,
published in the October issue of Drug Discovery Today, described the active site …

The cytochrome P450s are a superfamily of enzymes that are found in all kingdoms of living
organisms, and typically catalyze the oxidative addition of atomic oxygen to an unactivated …