Single‐cell profiling of bronchoalveolar cells reveals a Th17 signature in neutrophilic severe equine asthma
SE Sage, T Leeb, V Jagannathan, V Gerber - Immunology, 2024 - Wiley Online Library
Severe equine asthma (SEA) is a complex respiratory condition characterized by chronic
airway inflammation. It shares many clinical and pathological features with human …
airway inflammation. It shares many clinical and pathological features with human …
Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma
M Riihimäki, K Fegraeus, J Nordlund, I Waern… - Scientific Reports, 2023 - nature.com
Equine asthma (EA) is a heterogenous, complex disease, with a significant negative impact
on horse welfare and performance. EA and human asthma share fundamental similarities …
on horse welfare and performance. EA and human asthma share fundamental similarities …
[HTML][HTML] Single-cell gene expression analysis of cryopreserved equine bronchoalveolar cells
SE Sage, P Nicholson, LM Peters, T Leeb… - Frontiers in …, 2022 - frontiersin.org
The transcriptomic profile of a cell population can now be studied at the cellular level using
single-cell mRNA sequencing (scRNA-seq). This novel technique provides the …
single-cell mRNA sequencing (scRNA-seq). This novel technique provides the …
Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma
L Tessier, O Côté, ME Clark, L Viel, A Diaz-Méndez… - BMC genomics, 2017 - Springer
Background Severe equine asthma is a naturally occurring lung inflammatory disease of
mature animals characterized by neutrophilic inflammation, bronchoconstriction, mucus …
mature animals characterized by neutrophilic inflammation, bronchoconstriction, mucus …
Multidimensional analysis of bronchoalveolar lavage cytokines and mast cell proteases reveals Interferon-γ as a key biomarker in equine asthma syndrome
JS Woodrow, M Hines, C Sommardahl, B Flatland… - BioRxiv, 2020 - biorxiv.org
Naturally-occurring equine asthma is an inflammatory lung disease characterized by
chronic, partially reversible airway obstruction, pulmonary remodeling and lower airway …
chronic, partially reversible airway obstruction, pulmonary remodeling and lower airway …
[HTML][HTML] Initial investigation of molecular phenotypes of airway mast cells and cytokine profiles in equine asthma
JS Woodrow, M Hines, C Sommardahl… - Frontiers in Veterinary …, 2023 - frontiersin.org
Equine asthma is a naturally occurring lung disease characterized by chronic, partially
reversible airway obstruction, pulmonary remodeling, and lower airway inflammation …
reversible airway obstruction, pulmonary remodeling, and lower airway inflammation …
Flow cytometric analysis of equine bronchoalveolar lavage fluid cells in horses with and without severe equine asthma
H Kang, D Bienzle, GKC Lee, É Piché… - Veterinary …, 2022 - journals.sagepub.com
Severe equine asthma (SEA) is a common, debilitating lower airway inflammatory disorder
of older horses. Alveolar macrophages (AMs) survey inhaled particulates from barn sources …
of older horses. Alveolar macrophages (AMs) survey inhaled particulates from barn sources …
Asthma “of horses and men”—How can equine heaves help us better understand human asthma immunopathology and its functional consequences?
Animal models have been studied to unravel etiological, immunopathological, and genetic
attributes leading to asthma. However, while experiments in which the disease is artificially …
attributes leading to asthma. However, while experiments in which the disease is artificially …
The effect of race training on the basal gene expression of alveolar macrophages derived from standardbred racehorses
AE Karagianni, KM Summers, A Couroucé… - Journal of equine …, 2019 - Elsevier
Mild-to-moderate equine asthma is prevalent in young racehorses, particularly early in their
training period. Although the precise etiopathogenesis remains undetermined, it is possible …
training period. Although the precise etiopathogenesis remains undetermined, it is possible …
An Integrative miRNA-mRNA expression analysis reveals striking transcriptomic similarities between severe equine asthma and specific asthma endotypes in humans
MF Hulliger, A Pacholewska, A Vargas, JP Lavoie… - Genes, 2020 - mdpi.com
Severe equine asthma is an incurable obstructive respiratory condition affecting 10–15% of
horses in temperate climates. Upon exposure to airborne antigens from hay feeding …
horses in temperate climates. Upon exposure to airborne antigens from hay feeding …