Single‐cell profiling of bronchoalveolar cells reveals a Th17 signature in neutrophilic severe equine asthma

SE Sage, T Leeb, V Jagannathan, V Gerber - Immunology, 2024 - Wiley Online Library
Severe equine asthma (SEA) is a complex respiratory condition characterized by chronic
airway inflammation. It shares many clinical and pathological features with human …

Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma

M Riihimäki, K Fegraeus, J Nordlund, I Waern… - Scientific Reports, 2023 - nature.com
Equine asthma (EA) is a heterogenous, complex disease, with a significant negative impact
on horse welfare and performance. EA and human asthma share fundamental similarities …

[HTML][HTML] Single-cell gene expression analysis of cryopreserved equine bronchoalveolar cells

SE Sage, P Nicholson, LM Peters, T Leeb… - Frontiers in …, 2022 - frontiersin.org
The transcriptomic profile of a cell population can now be studied at the cellular level using
single-cell mRNA sequencing (scRNA-seq). This novel technique provides the …

Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma

L Tessier, O Côté, ME Clark, L Viel, A Diaz-Méndez… - BMC genomics, 2017 - Springer
Background Severe equine asthma is a naturally occurring lung inflammatory disease of
mature animals characterized by neutrophilic inflammation, bronchoconstriction, mucus …

Multidimensional analysis of bronchoalveolar lavage cytokines and mast cell proteases reveals Interferon-γ as a key biomarker in equine asthma syndrome

JS Woodrow, M Hines, C Sommardahl, B Flatland… - BioRxiv, 2020 - biorxiv.org
Naturally-occurring equine asthma is an inflammatory lung disease characterized by
chronic, partially reversible airway obstruction, pulmonary remodeling and lower airway …

[HTML][HTML] Initial investigation of molecular phenotypes of airway mast cells and cytokine profiles in equine asthma

JS Woodrow, M Hines, C Sommardahl… - Frontiers in Veterinary …, 2023 - frontiersin.org
Equine asthma is a naturally occurring lung disease characterized by chronic, partially
reversible airway obstruction, pulmonary remodeling, and lower airway inflammation …

Flow cytometric analysis of equine bronchoalveolar lavage fluid cells in horses with and without severe equine asthma

H Kang, D Bienzle, GKC Lee, É Piché… - Veterinary …, 2022 - journals.sagepub.com
Severe equine asthma (SEA) is a common, debilitating lower airway inflammatory disorder
of older horses. Alveolar macrophages (AMs) survey inhaled particulates from barn sources …

Asthma “of horses and men”—How can equine heaves help us better understand human asthma immunopathology and its functional consequences?

M Bullone, JP Lavoie - Molecular immunology, 2015 - Elsevier
Animal models have been studied to unravel etiological, immunopathological, and genetic
attributes leading to asthma. However, while experiments in which the disease is artificially …

The effect of race training on the basal gene expression of alveolar macrophages derived from standardbred racehorses

AE Karagianni, KM Summers, A Couroucé… - Journal of equine …, 2019 - Elsevier
Mild-to-moderate equine asthma is prevalent in young racehorses, particularly early in their
training period. Although the precise etiopathogenesis remains undetermined, it is possible …

An Integrative miRNA-mRNA expression analysis reveals striking transcriptomic similarities between severe equine asthma and specific asthma endotypes in humans

MF Hulliger, A Pacholewska, A Vargas, JP Lavoie… - Genes, 2020 - mdpi.com
Severe equine asthma is an incurable obstructive respiratory condition affecting 10–15% of
horses in temperate climates. Upon exposure to airborne antigens from hay feeding …