Although renal fibrosis can advance chronic kidney disease and progressively lead to end-
stage renal failure, no effective anti-fibrotic drugs have been clinically approved. To aid drug …

Renal fibrosis is a serious clinical problem resulting in the greatest need for renal
replacement therapy. No adequate preventive or curative therapy is available that could be …

Renal fibrosis is characterized by progressive accumulation of extracellular matrix (ECM)
proteins, resulting in loss of organ function and eventually requiring renal replacement …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Chronic kidney disease (CKD) is associated with renal fibrosis, a pathological process that
is characterized by excessive accumulation of extracellular matrix proteins resulting in loss …

Chronic kidney disease (CKD) leads to a gradual loss of kidney function, with fibrosis as
pathological endpoint, which is characterized by extracellular matrix (ECM) deposition and …

Animal models are a valuable tool in preclinical research. However, limited predictivity of
human biological responses in the conventional models has stimulated the search for …

Poor translation from animal studies to human clinical trials is one of the main hurdles in the
development of new drugs. Here, we used precision-cut kidney slices (PCKS) as a …

The kidney local microenvironment (KLM) plays a critical role in the pathogenesis of kidney
fibrosis. However, the composition and regulation of a fibrotic KLM remain unclear. Through …

In pharmacological research the development of promising lead compounds requires a
detailed understanding of the dynamics of disease progression. However, for many …