ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice
M Kornete, E Sgouroudis, CA Piccirillo - The Journal of Immunology, 2012 - journals.aai.org
A progressive waning in Foxp3+ regulatory T cell (Treg) functions is thought to provoke
autoimmunity in the NOD model of type 1 diabetes (T1D). A deficiency in IL-2 is one of the …
autoimmunity in the NOD model of type 1 diabetes (T1D). A deficiency in IL-2 is one of the …
[HTML][HTML] Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice
M Kornete, ES Mason, J Girouard, EI Lafferty… - PloS one, 2015 - journals.plos.org
Type 1 diabetes (T1D) occurs through a breakdown of self-tolerance resulting in the
autoimmune destruction of the insulin producing β-islets of the pancreas. A numerical and …
autoimmune destruction of the insulin producing β-islets of the pancreas. A numerical and …
Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system
N Prevot, C Briet, H Lassmann, I Tardivel… - European journal of …, 2010 - Wiley Online Library
NOD mice spontaneously develop insulin‐dependent diabetes around 10–40 wk of age.
Numerous immune gene variants contribute to the autoimmune process. However, genes …
Numerous immune gene variants contribute to the autoimmune process. However, genes …
Cutting edge: ICOS-deficient regulatory T cells display normal induction of Il10 but readily downregulate expression of Foxp3
AE Landuyt, BJ Klocke, TB Colvin… - The Journal of …, 2019 - journals.aai.org
The ICOS pathway has been implicated in the development and functions of regulatory T
(Treg) cells, including those producing IL-10. Treg cell–derived IL-10 is indispensable for the …
(Treg) cells, including those producing IL-10. Treg cell–derived IL-10 is indispensable for the …
ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice
D Hawiger, E Tran, W Du, CJ Booth, L Wen… - The Journal of …, 2008 - journals.aai.org
Initiation of diabetes in NOD mice can be mediated by the costimulatory signals received by
T cells. The ICOS is found on Ag-experienced T cells where it acts as a potent regulator of T …
T cells. The ICOS is found on Ag-experienced T cells where it acts as a potent regulator of T …
[HTML][HTML] CD4+ CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion
AE Herman, GJ Freeman, D Mathis… - The Journal of …, 2004 - ncbi.nlm.nih.gov
Abstract CD4+ CD25+ T regulatory cells (Tregs) prevent autoimmune disease, yet little is
known about precisely where they exert their influence naturally in a spontaneous …
known about precisely where they exert their influence naturally in a spontaneous …
Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice
MJI Ansari, P Fiorina, S Dada, I Guleria, T Ueno… - Clinical …, 2008 - Elsevier
Islet allografts are subject to alloimmune and autoimmune destruction when transplanted
into autoimmune prone animals or humans. The ICOS-B7h pathway plays a role in …
into autoimmune prone animals or humans. The ICOS-B7h pathway plays a role in …
ICOS mediates the generation and function of CD4+ CD25+ Foxp3+ regulatory T cells conveying respiratory tolerance
M Busse, M Krech, A Meyer-Bahlburg… - The Journal of …, 2012 - journals.aai.org
Costimulatory molecules like ICOS are crucial in mediating T cell differentiation and function
after allergen contact and thereby strongly affect the immunologic decision between …
after allergen contact and thereby strongly affect the immunologic decision between …
B cells polarize pathogenic inflammatory T helper subsets through ICOSL-dependent glycolysis
QH Zeng, Y Wei, XM Lao, DP Chen, CX Huang… - Science …, 2020 - science.org
B cells constitute abundant cellular components in inflamed human tissues, but their role in
pathogenesis of inflammatory T helper (TH) subsets is still unclear. Here, we demonstrate …
pathogenesis of inflammatory T helper (TH) subsets is still unclear. Here, we demonstrate …
β-Cell–Specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice
MC Johnson, AL Garland, SC Nicolson, C Li… - Diabetes, 2013 - Am Diabetes Assoc
Interleukin-2 (IL-2) is a critical cytokine for the homeostasis and function of forkhead box p3–
expressing regulatory T cells (Foxp3+ Tregs). Dysregulation of the IL-2–IL-2 receptor axis is …
expressing regulatory T cells (Foxp3+ Tregs). Dysregulation of the IL-2–IL-2 receptor axis is …
相关搜索
- regulatory t cells expression of foxp3
- regulatory t cells function of cd4
- nod mice icos pathway
- nod mice treg cells
- β islets treg cells
- nod mice β islets
- regulatory t cells respiratory tolerance
- regulatory t cells normal induction
- regulatory t cells cutting edge
- regulatory t cells generation and function
- nod mice β cell