ROS/mtROS promotes TNTs formation via the PI3K/AKT/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials

X Lin, W Wang, X Chang, C Chen, Z Guo, G Yu… - Particle and Fibre …, 2024 - Springer
Background As the demand and application of engineered nanomaterials have increased,
their potential toxicity to the central nervous system has drawn increasing attention …

Intercellular transfer of mitochondria via tunneling nanotubes protects against cobalt nanoparticle-induced neurotoxicity and mitochondrial damage

F Zheng, Z Luo, X Lin, W Wang, M Aschner, P Cai… - …, 2021 - Taylor & Francis
Broad applications of cobalt nanoparticles (CoNPs) have raised increased concerns
regarding their potential toxicity. However, the underlining mechanisms of their toxicity have …

Toxicity mechanism of engineered nanomaterials: Focus on mitochondria

Y Yao, T Zhang, M Tang - Environmental Pollution, 2023 - Elsevier
With the rapid development of nanotechnology, engineered nanomaterials (ENMs) are
widely used in various fields. This has exacerbated the environmental pollution and human …

Mitochondrial dysfunction in titanium dioxide nanoparticle-induced neurotoxicity

N Nalika, S Parvez - Toxicology mechanisms and methods, 2015 - Taylor & Francis
Nanotechnology has emerged as a field of scientific innovation which has opened up a
plethora of concerns for the potential impact on human and environment. Various …

Titanium dioxide nanoparticles promote oxidative stress, autophagy and reduce NLRP3 in primary rat astrocytes

JA Pérez-Arizti, JL Ventura-Gallegos… - Chemico-biological …, 2020 - Elsevier
Abstract Titanium dioxide nanoparticles (TiO 2-NPs) are widely used in the food industry,
cosmetics, personal care and paints among others. Through occupational exposure and …

Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy

A Raghavan, P Rao, J Neuzil, DL Pountney… - Cellular and Molecular …, 2021 - Springer
Tunnelling nanotubes (TNTs) are an emerging route of long-range intercellular
communication that mediate cell-to-cell exchange of cargo and organelles and contribute to …

[HTML][HTML] Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

B Song, Y Zhang, J Liu, X Feng… - Beilstein journal of …, 2016 - beilstein-journals.org
Abstract Titanium dioxide nanoparticles (TiO 2 NPs) possess unique characteristics and are
widely used in many fields. Numerous in vivo studies, exposing experimental animals to …

Mitochondrial dysfunction and loss of glutamate uptake in primary astrocytes exposed to titanium dioxide nanoparticles

CL Wilson, V Natarajan, SL Hayward, O Khalimonchuk… - Nanoscale, 2015 - pubs.rsc.org
Titanium dioxide (TiO2) nanoparticles are currently the second most produced engineered
nanomaterial in the world with vast usage in consumer products leading to recurrent human …

Tunneling nanotubes-mediated protection of mesenchymal stem cells: an update from preclinical studies

T Soundara Rajan, A Gugliandolo, P Bramanti… - International Journal of …, 2020 - mdpi.com
Tunneling nanotubes (TNTs) are thin membrane elongations among the cells that mediate
the trafficking of subcellular organelles, biomolecules, and cues. Mesenchymal stem cells …

ROS-mediated NRF2/p-ERK1/2 signaling-involved mitophagy contributes to macrophages activation induced by CdTe quantum dots

N Liu, Y Liang, T Wei, X Huang, T Zhang, M Tang - Toxicology, 2024 - Elsevier
Cadmium telluride (CdTe) quantum dots (QDs) have garnered significant attention for tumor
imaging due to their exceptional properties. However, there remains a need for further …