Background The cause of preeclampsia remains unclear. Limited data suggest that excess
circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor …

OBJECTIVE: The objective of the study was to evaluate angiogenic factors for the prediction
of preeclampsia in high-risk women. STUDY DESIGN: We collected serial serum specimens …

Background—An imbalance in circulating angiogenic factors plays a central role in the
pathogenesis of preeclampsia. Methods and Results—We prospectively studied 616 women …

Preeclampsia is far more common in women's first pregnancy but the mechanism of this
association is unknown. Altered angiogenesis, marked by increased levels of circulating …

Background Differences in circulating concentrations of antiangiogenic factors sFlt1 and
soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede …

OBJECTIVE: To estimate whether alterations in plasma levels of the proangiogenic proteins
placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A), and the …

OBJECTIVE: To estimate the relationship between maternal serum levels of placental
growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in early pregnancy with …

OBJECTIVE: To evaluate claims that elevated soluble fms-like tyrosine kinase-1 receptor
(sFlt-1) and decreased placental growth factor predict preeclampsia. DATA SOURCES …

OBJECTIVE: The purpose of this study was to examine whether longitudinally sampled
maternal angiogenic concentrations predict preeclampsia. STUDY DESIGN: Plasma sFlt-1 …

Preeclampsia is caused by placental impairment with increased expression of sFlt-1
(soluble fms-like tyrosine kinase 1) and decreased PlGF (placental growth factor); it has …