External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice

M Baker, S Kang, SI Hong, M Song, MA Yang… - Nature …, 2023 - nature.com
The external globus pallidus (GPe) coordinates action-selection through GABAergic
projections throughout the basal ganglia. GPe arkypallidal (arky) neurons project exclusively …

Astrocyte activities in the external globus pallidus regulate action-selection strategies in reward-seeking behaviors

S Kang, SI Hong, S Kang, M Song, MA Yang… - Science …, 2023 - science.org
An imbalance in goal-directed and habitual behavioral control is a hallmark of decision-
making–related disorders, including addiction. Although external globus pallidus (GPe) is …

Dissociable roles of ventral pallidum neurons in the basal ganglia reinforcement learning network

A Kaplan, AD Mizrahi-Kliger, Z Israel, A Adler… - Nature …, 2020 - nature.com
Reinforcement learning models treat the basal ganglia (BG) as an actor–critic network. The
ventral pallidum (VP) is a major component of the BG limbic system. However, its precise …

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

SV Mahler, EM Vazey, JT Beckley, CR Keistler… - Nature …, 2014 - nature.com
The ventral pallidum is centrally positioned within mesocorticolimbic reward circuits, and its
dense projection to the ventral tegmental area (VTA) regulates neuronal activity there …

Selective encoding of reward predictions and prediction errors by globus pallidus subpopulations

MA Farries, TW Faust, A Mohebi, JD Berke - Current Biology, 2023 - cell.com
Basal ganglia (BG) circuits help guide and invigorate actions using predictions of future
rewards (values). Within the BG, the globus pallidus pars externa (GPe) may play an …

Ventral pallidum GABA neurons mediate motivation underlying risky choice

MR Farrell, JSD Esteban, L Faget… - Journal of …, 2021 - Soc Neuroscience
Pursuing rewards while avoiding danger is an essential function of any nervous system.
Here, we examine a new mechanism helping rats negotiate the balance between risk and …

Opposing contributions of GABAergic and glutamatergic ventral pallidal neurons to motivational behaviors

M Stephenson-Jones, C Bravo-Rivera, S Ahrens… - Neuron, 2020 - cell.com
The ventral pallidum (VP) is critical for invigorating reward seeking and is also involved in
punishment avoidance, but how it contributes to such opposing behavioral actions remains …

Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens

D Ottenheimer, JM Richard, PH Janak - Nature communications, 2018 - nature.com
The ventral striatopallidal system, a basal ganglia network thought to convert limbic
information into behavioral action, includes the nucleus accumbens (NAc) and the ventral …

Dopamine signaling in the dorsomedial striatum promotes compulsive behavior

JL Seiler, CV Cosme, VN Sherathiya, MD Schaid… - Current Biology, 2022 - cell.com
Compulsive behavior is a defining feature of disorders such as substance use disorders.
Current evidence suggests that corticostriatal circuits control the expression of established …

Pallidal spiking activity reflects learning dynamics and predicts performance

E Schechtman, MI Noblejas… - Proceedings of the …, 2016 - National Acad Sciences
The basal ganglia (BG) network has been divided into interacting actor and critic
components, modulating the probabilities of different state–action combinations through …