GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis
Background Twin studies have demonstrated that both genetic and environmental factors
influence risk for posttraumatic stress disorder (PTSD), and there is some evidence …
influence risk for posttraumatic stress disorder (PTSD), and there is some evidence …
The effects of early trauma and the FKBP5 gene on PTSD and the HPA axis in a clinical sample of Gulf War veterans
DA Young, SS Inslicht, TJ Metzler, TC Neylan… - Psychiatry research, 2018 - Elsevier
Previous research indicates that interactions between FKBP5 single nucleotide
polymorphisms (SNPs) and child abuse are associated with posttraumatic stress disorder …
polymorphisms (SNPs) and child abuse are associated with posttraumatic stress disorder …
[HTML][HTML] Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
FKBP5 regulates the cortisol-binding affinity and nuclear translocation of the glucocorticoid
receptor. Polymorphisms at the FKBP5 locus have been associated with increased …
receptor. Polymorphisms at the FKBP5 locus have been associated with increased …
FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study
Polymorphisms in the FK506 Binding Protein 5 (FKBP5) gene may interact with childhood
abuse to increase risk of developing posttraumatic stress disorder (PTSD) symptoms. The …
abuse to increase risk of developing posttraumatic stress disorder (PTSD) symptoms. The …
Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
EB Binder, RG Bradley, W Liu, MP Epstein, TC Deveau… - Jama, 2008 - jamanetwork.com
Context In addition to trauma exposure, other factors contribute to risk for development of
posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors …
posttraumatic stress disorder (PTSD) in adulthood. Both genetic and environmental factors …
Attachment style moderates effects of FKBP5 polymorphisms and childhood abuse on post-traumatic stress symptoms: Results from the National Health and …
Objectives: To determine the main and interactive effects of four FKBP5 polymorphisms
(rs9296158, rs3800373, rs1360780 and rs9470080), childhood abuse and attachment style …
(rs9296158, rs3800373, rs1360780 and rs9470080), childhood abuse and attachment style …
Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis
Q Wang, RC Shelton, Y Dwivedi - Journal of affective disorders, 2018 - Elsevier
Background Gene-environment interaction contributes to the risks of psychiatric disorders.
Interactions between FKBP5 gene variants and early-life stress may enhance the risk not …
Interactions between FKBP5 gene variants and early-life stress may enhance the risk not …
[HTML][HTML] The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder
Exposure-based therapies are considered the state-of-the-art treatment for Posttraumatic
Stress Disorder (PTSD). Yet, a substantial number of PTSD patients do not recover after …
Stress Disorder (PTSD). Yet, a substantial number of PTSD patients do not recover after …
Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies
Context Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co-
chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an …
chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an …
Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric …
JA Boscarino, PM Erlich, SN Hoffman… - … disease and treatment, 2012 - Taylor & Francis
Objective The study aim was to assess the cumulative burden of polymorphisms located
within four genetic loci previously associated with posttraumatic stress disorder (PTSD) …
within four genetic loci previously associated with posttraumatic stress disorder (PTSD) …