Mitochondria: their role in spermatozoa and in male infertility

M Boguenet, PE Bouet, A Spiers… - Human …, 2021 - academic.oup.com
BACKGROUND The best-known role of spermatozoa is to fertilize the oocyte and to transmit
the paternal genome to offspring. These highly specialized cells have a unique structure …

Mitochondria, spermatogenesis, and male infertility–An update

S Vertika, KK Singh, S Rajender - Mitochondrion, 2020 - Elsevier
The incorporation of mitochondria in the eukaryotic cell is one of the most enigmatic events
in the course of evolution. This important organelle was thought to be only the powerhouse …

Mitochondria, spermatogenesis and male infertility

S Rajender, P Rahul, AA Mahdi - Mitochondrion, 2010 - Elsevier
Mitochondria and its role in male reproduction has remained an enigma since long.
Similarly, etiology of male infertility in a large percentage of individuals, mainly primary …

Mitochondria functionality and sperm quality

A Amaral, B Lourenço, M Marques… - …, 2013 - rep.bioscientifica.com
Although mitochondria are best known for being the eukaryotic cell powerhouses, these
organelles participate in various cellular functions besides ATP production, such as calcium …

Causes and consequences of sperm mitochondrial dysfunction

D Durairajanayagam, D Singh, A Agarwal… - Andrologia, 2021 - Wiley Online Library
Mitochondria have multiple functions, including synthesis of adenine triphosphate,
production of reactive oxygen species, calcium signalling, thermogenesis and apoptosis …

Mitochondrial functionality in male fertility: from spermatogenesis to fertilization

YJ Park, MG Pang - Antioxidants, 2021 - mdpi.com
Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

The sperm mitochondrion: Organelle of many functions

CR Moraes, S Meyers - Animal reproduction science, 2018 - Elsevier
This review summarizes current research in sperm mitochondrial function with specific
emphasis on mitochondrial metabolism, reactive oxygen species production and …

Pathophysiology of mitochondrial dysfunction in human spermatozoa: focus on energetic metabolism, oxidative stress and apoptosis

C Castellini, S D'Andrea, G Cordeschi, M Totaro… - Antioxidants, 2021 - mdpi.com
The dogma of mitochondria as the major source of energy in supporting sperm motility
should be critically reconsidered in the light of several experimental data pointing to a major …

Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells

J Ramalho-Santos, S Varum, S Amaral… - Human reproduction …, 2009 - academic.oup.com
BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

Mitochondrial dynamics during spermatogenesis

G Varuzhanyan, DC Chan - Journal of cell science, 2020 - journals.biologists.com
Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that
safeguard normal cellular function. This relationship is especially strong in tissues with …