High altitudes (> 8,000 ft or 2,500 m) provide an experiment of nature for measuring
adaptation and the physiological processes involved. Studies conducted over the past~ 25 …

Whether Andean populations are genetically adapted to high altitudes has long been of
interest. Initial studies focused on physiological changes in the O2 transport system that …

Abstract Simonson, Tatum S. Altitude adaptation: A glimpse through various lenses. High Alt
Med Biol 16: 125–137, 2015.—Recent availability of genome-wide data from highland …

Over the past decade, major technological and analytical advancements have propelled
efforts toward identifying the molecular mechanisms that govern human adaptation to high …

High-altitude natives have distinctive biological characteristics that appear to offset the
stress of hypoxia. Evolutionary theory reasons that they reflect genetic adaptations resulting …

High-altitude environments provide natural experimental settings to investigate adaptation to
environmental stress. An important evolutionary and functional question is whether sea-level …

High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric
pressure) exerts severe physiological stress on the human body. Two high-altitude regions …

Objectives High‐altitude hypoxia, or decreased oxygen levels caused by low barometric
pressure, challenges the ability of humans to live and reproduce. Despite these challenges …

Objectives This report presents a perspective on the broad research trends in the biology of
human populations at high‐altitude and their contributions to the improved understanding of …

Humans have occupied the high plateaus and mountain valleys of the Andes and the
Himalayas for thousands of years. Although sea level natives can, and often do, travel in …