Porcine models for studying complications and organ crosstalk in diabetes mellitus

S Renner, A Blutke, S Clauss, CA Deeg, E Kemter… - Cell and tissue …, 2020 - Springer
The worldwide prevalence of diabetes mellitus and obesity is rapidly increasing not only in
adults but also in children and adolescents. Diabetes is associated with macrovascular …

[PDF][PDF] Animal models of diabetes mellitus: relevance to vascular complications

CS Thompson - Current pharmaceutical design, 2008 - researchgate.net
The prevalence of diabetes mellitus is increasing worldwide at an alarming rate due to
population growth, obesity, sedentary lifestyle and aging. Consequently, diabetic …

Animal models of diabetic macrovascular complications: key players in the development of new therapeutic approaches

SE Heinonen, G Genové, E Bengtsson… - Journal of diabetes …, 2015 - Wiley Online Library
Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic
macrovascular complications (coronary heart disease, stroke, and peripheral vascular …

[HTML][HTML] The Munich MIDY Pig Biobank–A unique resource for studying organ crosstalk in diabetes

A Blutke, S Renner, F Flenkenthaler, M Backman… - Molecular …, 2017 - Elsevier
Objective The prevalence of diabetes mellitus and associated complications is steadily
increasing. As a resource for studying systemic consequences of chronic insulin …

Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals

R Robinson, VA Barathi, SS Chaurasia… - Disease models & …, 2012 - journals.biologists.com
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and
one of the major causes of blindness worldwide. The pathogenesis of DR has been …

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research

S Renner, B Dobenecker, A Blutke, S Zoels, R Wanke… - Theriogenology, 2016 - Elsevier
The prevalence of diabetes mellitus, which currently affects 387 million people worldwide, is
permanently rising in both adults and adolescents. Despite numerous treatment options …

The use of animal models in the study of diabetes mellitus

A Chatzigeorgiou, A Halapas, K Kalafatakis, E Kamper - In vivo, 2009 - iv.iiarjournals.org
Animal models have enormously contributed to the study of diabetes mellitus, a metabolic
disease with abnormal glucose homeostasis, due to some defect in the secretion or the …

Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition

WT Cefalu - ILAR journal, 2006 - academic.oup.com
The prevalence of diabetes throughout the world has increased dramatically over the recent
past, and the trend will continue for the foreseeable future. One of the major concerns …

Animal models of diabetic retinopathy

X Jiang, L Yang, Y Luo - Current Eye Research, 2015 - Taylor & Francis
Diabetic retinopathy (DR) is one of today's main causes of blindness in numerous
developed countries worldwide. The underlying pathogenesis of DR is complex and not well …

Development and application of rodent models for type 2 diabetes

D Chen, MW Wang - Diabetes, Obesity and metabolism, 2005 - Wiley Online Library
The increasing worldwide incidence of diabetes in adults constitutes a global public health
burden. It is predicted that by 2025, India, China and the United States will have the largest …