Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering
N Vunnam, MC Young, EE Liao, CH Lo… - Cancer Biology & …, 2023 - Taylor & Francis
Nimesulide is a nonsteroidal anti-inflammatory drug and a COX-2 inhibitor with antitumor
and antiproliferative activities that induces apoptosis in oral, esophagus, breast, and …
and antiproliferative activities that induces apoptosis in oral, esophagus, breast, and …
LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization
TW Poh, S Huang, JL Hirpara, S Pervaiz - Cell Death & Differentiation, 2007 - nature.com
Certain classes of tumor cells respond favorably to TRAIL due to the presence of cell surface
death receptors DR4 and DR5. Despite this preferential sensitivity, resistance to TRAIL …
death receptors DR4 and DR5. Despite this preferential sensitivity, resistance to TRAIL …
[HTML][HTML] Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5
X Di, G Zhang, Y Zhang, K Takeda, LAR Rosado… - Oncotarget, 2013 - ncbi.nlm.nih.gov
TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis through death receptors
(DRs) 4 and/or 5 expressed on the surface of target cells. We have previously shown that …
(DRs) 4 and/or 5 expressed on the surface of target cells. We have previously shown that …
[HTML][HTML] Spatial dynamics of TRAIL death receptors in cancer cells
JD Twomey, SR Kim, L Zhao, WP Bozza… - Drug Resistance Updates, 2015 - Elsevier
TNF-related apoptosis inducing ligand (TRAIL) selectively induces apoptosis in cancer cells
without harming most normal cells. Currently, multiple clinical trials are underway to …
without harming most normal cells. Currently, multiple clinical trials are underway to …
A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death
O Bucur, G Gaidos, A Yatawara, B Pennarun… - Scientific reports, 2015 - nature.com
Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and
DR5) are currently being created for clinical cancer therapy, due to their selective killing of …
DR5) are currently being created for clinical cancer therapy, due to their selective killing of …
Death receptor 5 displayed on extracellular vesicles decreases TRAIL sensitivity of colon cancer cells
R Setroikromo, B Zhang, CR Reis, RH Mistry… - Frontiers in cell and …, 2020 - frontiersin.org
Tumor necrosis factor–related apoptosis inducing ligand (TRAIL) is considered to be a
promising antitumor drug because of its selective proapoptotic properties on tumor cells …
promising antitumor drug because of its selective proapoptotic properties on tumor cells …
DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death
TNF-related apoptosis-inducing ligand (TRAIL) resistance, including nongenetically
acquired tolerance in cancer persister cells, is a major obstacle to translating TRAIL therapy …
acquired tolerance in cancer persister cells, is a major obstacle to translating TRAIL therapy …
Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors
T Bagci-Onder, A Agarwal, D Flusberg, S Wanningen… - Oncogene, 2013 - nature.com
Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis
specifically in tumor cells and its efficacy has been tested in pre-clinical models by delivering …
specifically in tumor cells and its efficacy has been tested in pre-clinical models by delivering …
Small-molecule activation of the TRAIL receptor DR5 in human cancer cells
G Wang, X Wang, H Yu, S Wei, N Williams… - Nature chemical …, 2013 - nature.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) activates apoptosis
through the death receptors DR4 and DR5. Because of its superior safety profile and high …
through the death receptors DR4 and DR5. Because of its superior safety profile and high …
Kinome profiling of non-canonical TRAIL signaling reveals RIP1–Src–STAT3-dependent invasion in resistant non-small cell lung cancer cells
K Azijli, S Yuvaraj, MP Peppelenbosch… - Journal of cell …, 2012 - journals.biologists.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) triggers apoptosis
selectively in tumor cells through interaction with TRAIL-R1/DR4 or TRAIL-R2/DR5 and this …
selectively in tumor cells through interaction with TRAIL-R1/DR4 or TRAIL-R2/DR5 and this …