Ferredoxin 1b deficiency leads to testis disorganization, impaired spermatogenesis, and feminization in zebrafish
The roles of steroids in zebrafish sex differentiation, gonadal development, and function of
the adult gonad are poorly understood. Herein, we used ferredoxin 1b (fdx1b) mutant …
the adult gonad are poorly understood. Herein, we used ferredoxin 1b (fdx1b) mutant …
Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish
Mitochondrial cytochrome P450 (CYP) enzymes rely on electron transfer from the redox
partner ferredoxin 1 (FDX1) for catalytic activity. Key steps in steroidogenesis require …
partner ferredoxin 1 (FDX1) for catalytic activity. Key steps in steroidogenesis require …
11β-Hydroxylase loss disrupts steroidogenesis and reproductive function in zebrafish
JA Oakes, L Barnard, KH Storbeck… - Journal of …, 2020 - joe.bioscientifica.com
The roles of androgens in male reproductive development and function in zebrafish are
poorly understood. To investigate this topic, we employed CRISPR/Cas9 to generate …
poorly understood. To investigate this topic, we employed CRISPR/Cas9 to generate …
Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes
J von Hofsten, PE Olsson - Reproductive Biology and Endocrinology, 2005 - Springer
Sex determination is the process deciding the sex of a developing embryo. This is usually
determined genetically; however it is a delicate process, which in many cases can be …
determined genetically; however it is a delicate process, which in many cases can be …
New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis
Y Ruan, X Li, X Wang, G Zhai, Q Lou, X Jin, J He… - Plos …, 2024 - journals.plos.org
The regulatory mechanism of gonadal sex differentiation, which is complex and regulated by
multiple factors, remains poorly understood in teleosts. Recently, we have shown that …
multiple factors, remains poorly understood in teleosts. Recently, we have shown that …
Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co‐factors in zebrafish
The spatial and temporal expression of steroidogenic genes in zebrafish has not been fully
characterised. Because zebrafish are increasingly employed in endocrine and stress …
characterised. Because zebrafish are increasingly employed in endocrine and stress …
Disruption of dmrt1 rescues the all-male phenotype of the cyp19a1a mutant in zebrafish – a novel insight into the roles of aromatase/estrogens in gonadal …
Sex determination and differentiation are complex processes controlled by many different
factors; however, the relationships among these factors are poorly understood. Zebrafish …
factors; however, the relationships among these factors are poorly understood. Zebrafish …
Disruption of deiodinase type 2 in zebrafish disturbs male and female reproduction
AM Houbrechts, VM Darras - Journal of Endocrinology, 2019 - joe.bioscientifica.com
Thyroid hormones are crucial mediators of many aspects of vertebrate life, including
reproduction. The key player is the biologically active 3, 5, 3'-triiodothyronine (T 3), whose …
reproduction. The key player is the biologically active 3, 5, 3'-triiodothyronine (T 3), whose …
nr0b1 (DAX1) mutation in zebrafish causes female-to-male sex reversal through abnormal gonadal proliferation and differentiation
Sex determinations are diverse in vertebrates. Although many sex-determining genes and
pathways are conserved, the mechanistic roles of these genes and pathways in the genetic …
pathways are conserved, the mechanistic roles of these genes and pathways in the genetic …
Thyroid hormones deficiency impairs male germ cell development: a cross talk between hypothalamic-Pituitary-thyroid, and—gonadal axes in Zebrafish
MS Rodrigues, A Tovo-Neto, IF Rosa… - Frontiers in Cell and …, 2022 - frontiersin.org
In vertebrates, thyroid hormones are critical players in controlling different physiological
processes such as development, growth, metabolism among others. There is evidence in …
processes such as development, growth, metabolism among others. There is evidence in …