One of the most common approaches for control of skin pigmentation involves the inhibition
of tyrosinase, a copper-containing enzyme which catalyzes the key steps of melanogenesis …

Tyrosinase is a multifunctional glycosylated and copper-containing oxidase that is highly
prevalent in plants and animals and plays a pivotal role in catalyzing the two key steps of …

Human tyrosinase (hs TYR) is the key enzyme ensuring the conversion of l-tyrosine to
dopaquinone, thereby initiating melanin synthesis, ie, melanogenesis. Although the protein …

Tyrosinase is a copper‐containing enzyme, which is widely distributed in microorganisms,
animals and plants and is a key enzyme in melanin biosynthesis, involved in determining …

Melanin, a major pigment in mammalian skin, is known to protect the skin against harmful
effects of ultraviolet (UV) irradiation, oxidative stress, and DNA damage. The accumulation …

The inhibition of tyrosinase is one of the major strategies to treat hyperpigmentation. Various
limitations are associated with many of these inhibitors, such as high cytotoxicity, poor skin …

Tyrosinase plays a pivotal role in the synthesis of melanin pigment synthesis on skin utilizing
tyrosine as a substrate. Melanin is responsible for the protection against harmful ultraviolet …

Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …

Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which
catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic …

Tyrosinase is a key enzyme target to design new chemical ligands against melanogenesis.
In the current review, different chemical derivatives are explored which have been used as …