Small extracellular vesicles (exosomes) and their cargo in pancreatic cancer: Key roles in the hallmarks of cancer

LM Channon, VM Tyma, Z Xu, DW Greening… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Pancreatic cancer (PC) is a devastating disease, offering poor mortality rates for patients.
The current challenge being faced is the inability to diagnose patients in a timely manner …

[HTML][HTML] Pancreatic cancer small extracellular vesicles (exosomes): a tale of short-and long-distance communication

M Waldenmaier, T Seibold, T Seufferlein, T Eiseler - Cancers, 2021 - mdpi.com
Simple Summary Even today, pancreatic cancer still has a dismal prognosis. It is
characterized by a lack of early symptoms and thus late diagnosis as well as early …

[HTML][HTML] Thinking small to win big? A critical review on the potential application of extracellular vesicles for biomarker discovery and new therapeutic approaches in …

M Vahabi, A Comandatore, C Centra… - Seminars in Cancer …, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely deadly form of cancer, with
limited progress in 5-year survival rates despite significant research efforts. The main …

[HTML][HTML] Extracellular vesicle-dependent cross-talk in cancer—focus on pancreatic cancer

L Nannan, JB Oudart, JC Monboisse, L Ramont… - Frontiers in …, 2020 - frontiersin.org
Extracellular vesicles (EVs) like exosomes and shed microvesicles are generated by many
different cells. However, among all the cells, cancer cells are now recognized to secrete …

[HTML][HTML] Diagnostic and prognostic role of extracellular vesicles in pancreatic cancer: current evidence and future perspectives

A Nicoletti, M Negri, M Paratore, F Vitale… - International Journal of …, 2023 - mdpi.com
Pancreatic cancer is one of the most aggressive tumors, with a dismal prognosis due to poor
detection rates at early stages, rapid progression, post-surgical complications, and limited …

[HTML][HTML] Exosomes as pleiotropic players in pancreatic cancer

L De Lellis, R Florio, MC Di Bella, D Brocco, F Guidotti… - Biomedicines, 2021 - mdpi.com
Pancreatic cancer (PC) incidence is rising and due to late diagnosis, combined with
unsatisfactory response to current therapeutic approaches, this tumor has an extremely high …

[HTML][HTML] Tumour-derived exosomes as a signature of pancreatic cancer-liquid biopsies as indicators of tumour progression

Z Nuzhat, V Kinhal, S Sharma, GE Rice, V Joshi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Pancreatic cancer is the fourth most common cause of death due to cancer in the world. It is
known to have a poor prognosis, mostly because early stages of the disease are generally …

[HTML][HTML] Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications

J Qiu, G Yang, M Feng, S Zheng, Z Cao, L You… - Molecular cancer, 2018 - Springer
Pancreatic cancer is one of the most lethal cancers worldwide due to its insidious symptoms,
early metastasis, and chemoresistance. Hence, the underlying mechanisms contributing to …

[HTML][HTML] Exosomes in the treatment of pancreatic cancer: a moonshot to PDAC treatment?

SP Papadakos, N Dedes, A Pergaris… - International Journal of …, 2022 - mdpi.com
Pancreatic Ductal Adenocarcinoma (PDAC) constitutes a leading cause of cancer death
globally. Its mortality remains unaltered despite the considerable scientific progress made in …

Exosomes in pancreatic cancer: from early detection to treatment

EA Armstrong, EW Beal, J Chakedis… - Journal of …, 2018 - Elsevier
Background Pancreatic cancer (PC) remains one of the most fatal forms of cancer worldwide
with incidence nearly equal to mortality. This is often attributed to the fact that diagnosis is …