Importance In 2023, the American Heart Association (AHA) developed the Predicting Risk of
Cardiovascular Disease Events (PREVENT) equations to estimate 10-year risk of …

Importance Current guidelines recommend statin therapy for millions of US residents for the
primary prevention of atherosclerotic cardiovascular disease (ASCVD). It is unclear whether …

Clinical guidelines for initiation of statin therapy and antihypertensive therapy rely in part on
the calculation of a patient's 10-year risk of atherosclerotic cardiovascular disease (ASCVD) …

Objective Patients with risk factors for or established atherosclerotic cardiovascular disease
(ASCVD) remain at high risk for subsequent ischemic events despite statin therapy …

Importance The American College of Cardiology/American Heart Association (ACC/AHA)
Pooled Cohort risk equations were developed to estimate atherosclerotic cardiovascular …

ACC/AHA Pooled Cohort Risk Equations predicted 5-y risk for CV events in adults considered
for statin initiation | Annals of Internal Medicine Advertisement ACP Online Annals of Internal …

Background: The 2013 pooled cohort equations (PCEs) are central in prevention guidelines
for cardiovascular disease (CVD) but can misestimate CVD risk. Objective: To improve the …

Importance For primary prevention of atherosclerotic cardiovascular disease (ASCVD), the
2021 European Society of Cardiology (ESC) guidelines on statin use (hereafter European …

Roughly 45 million people in the US take statins, the cholesterollowering medications used
to prevent cardiovascular disease. Many patients without heart disease, though, are taking …

Background Healthy People 2020 aim to reduce fatal atherosclerotic cardiovascular disease
(ASCVD) by 20%, which translates into 310 000 fewer events annually assuming …