Hepatic CD206-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection
K Dai, L Huang, X Sun, L Yang… - Journal of Leucocyte …, 2015 - academic.oup.com
Hepatitis B virus is a major cause of chronic liver inflammation worldwide. Innate and
adaptive immune responses work together to restrain or eliminate hepatitis B virus in the …
adaptive immune responses work together to restrain or eliminate hepatitis B virus in the …
Amphiregulin promotes the immunosuppressive activity of intrahepatic CD4+ regulatory T cells to impair CD8+ T‐cell immunity against hepatitis B virus infection
K Dai, L Huang, J Chen, L Yang, Z Gong - Immunology, 2015 - Wiley Online Library
Hepatitis B virus (HBV) infection causes liver diseases and hepatocellular carcinoma.
Immunotolerance in HBV‐infected patients is one of the factors that incur failure of HBV …
Immunotolerance in HBV‐infected patients is one of the factors that incur failure of HBV …
[HTML][HTML] Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells
CH Yuan, XM Sun, CL Zhu, SP Liu, L Wu, H Chen… - Oncotarget, 2015 - ncbi.nlm.nih.gov
CD8+ T cell-mediated immune response plays an important role in inhibiting progression of
hepatocellular carcinoma (HCC). For strategic immunotherapy, it is critical to understand …
hepatocellular carcinoma (HCC). For strategic immunotherapy, it is critical to understand …
Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells
Recognition of virus infections by pattern recognition receptors (PRRs), such as Toll-like
receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation …
receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation …
[HTML][HTML] Identification of pro-inflammatory CD205+ macrophages in livers of hepatitis B virus transgenic mice and patients with chronic hepatitis B
L Yong, M Li, Y Gao, Y Deng, W Liu, D Huang… - Scientific Reports, 2017 - nature.com
Hepatic macrophages play a central role in disease pathogenesis during hepatitis B virus
(HBV) infection. Our previous study found that CD205+ macrophages in the liver of hepatitis …
(HBV) infection. Our previous study found that CD205+ macrophages in the liver of hepatitis …
[HTML][HTML] Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant …
J Kashiwakura, K Saitoh, T Ihara, Y Sasaki… - Plos one, 2020 - journals.plos.org
Objective Signal-transducing adaptor protein (STAP) family members function as adaptor
molecules and are involved in several events during immune responses. Notably however …
molecules and are involved in several events during immune responses. Notably however …
Hepatitis C virus infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathways and required for efficient viral …
R Pei, H Chen, L Lu, W Zhu… - Journal of general …, 2011 - microbiologyresearch.org
Amphiregulin (AREG) is a ligand of the epidermal growth factor (EGF) receptor and may play
a role in the development of cirrhosis and hepatocellular carcinoma in patients infected with …
a role in the development of cirrhosis and hepatocellular carcinoma in patients infected with …
Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses
Z Ma, E Zhang, D Yang, M Lu - Cellular & molecular immunology, 2015 - nature.com
It is well accepted that adaptive immunity plays a key role in the control of hepatitis B virus
(HBV) infection. In contrast, the contribution of innate immunity has only received attention in …
(HBV) infection. In contrast, the contribution of innate immunity has only received attention in …
A MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model
CR Leong, H Oshiumi, M Okamoto, M Azuma… - Journal of innate …, 2014 - karger.com
Toll-like receptors (TLRs) and cytoplasmic RNA sensors have been reported to be involved
in the regulation of hepatitis B virus (HBV) replication, but remain controversial due to the …
in the regulation of hepatitis B virus (HBV) replication, but remain controversial due to the …
[HTML][HTML] Hepatitis B core antigen impairs the polarization while promoting the production of inflammatory cytokines of M2 macrophages via the TLR2 pathway
H Yi, Y Zhang, X Yang, M Li, H Hu, J Xiong… - Frontiers in …, 2020 - frontiersin.org
Although several evidences suggesting the vital roles that innate immunity plays in the
persistence and elimination of chronic hepatitis B virus (CHB) infection, the exact …
persistence and elimination of chronic hepatitis B virus (CHB) infection, the exact …