The endocannabinoid system: physiology and pharmacology

F Rodríguez de Fonseca, I Del Arco… - Alcohol and …, 2005 - academic.oup.com
The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

The endocannabinoid system

A Kilaru, KD Chapman - Essays in Biochemistry, 2020 - portlandpress.com
Thirty years ago, the discovery of a cannabinoid (CB) receptor that interacts with the
psychoactive compound in Cannabis led to the identification of anandamide, an …

The endocannabinoid system as an emerging target of pharmacotherapy

P Pacher, S Bátkai, G Kunos - Pharmacological reviews, 2006 - ASPET
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation

V Di Marzo - Pharmacological research, 2009 - Elsevier
The endocannabinoid signalling system includes:(1) at least two G-protein-coupled
receptors, known as the cannabinoid CB1 and CB2 receptors and discovered following …

The endocannabinoid system as a target for therapeutic drugs

D Piomelli, A Giuffrida, A Calignano… - Trends in …, 2000 - cell.com
Cannabinoid receptors, the molecular targets of the cannabis constituent Δ 9-
tetrahydrocannabinol, are present throughout the body and are normally bound by a family …

Goods and bads of the endocannabinoid system as a therapeutic target: Lessons learned after 30 years

M Maccarrone, V Di Marzo, J Gertsch, U Grether… - Pharmacological …, 2023 - ASPET
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

[PDF][PDF] Endocannabinoid system: an overview of its potential in current medical practice

Z Mouslech, V Valla - Neuroendocrinology Letters, 2009 - researchgate.net
The endocannabinoid system (ECS) is a lipid signalling system, comprising of the
endogenous cannabis-like ligands (endocannabinoids) anandamide (AEA) and 2 …

Endocannabinoid metabolic pathways and enzymes

A Ligresti, MG Cascio, VD Marzo - Current Drug Targets-CNS …, 2005 - ingentaconnect.com
Endocannabinoid Metabolic Pathways and Enzymes Page 1 Current Drug Targets - CNS &
Neurological Disorders, 2005, 4, 615-623 615 1568-007X/05 $50.00+.00 © 2005 Bentham …

The biosynthesis, fate and pharmacological properties of endocannabinoids

V Di Marzo, T Bisogno, L De Petrocellis - Cannabinoids, 2005 - Springer
The finding of endogenous ligands for cannabinoid receptors, the endocannabinoids,
opened a new era in cannabinoid research. It meant that the biological role of cannabinoid …

The endocannabinoid system: a general view and latest additions

LD Petrocellis, MG Cascio… - British journal of …, 2004 - Wiley Online Library
After the discovery, in the early 1990s, of specific G‐protein‐coupled receptors for
marijuana's psychoactive principle Δ9‐tetrahydrocannabinol, the cannabinoid receptors …