Membrane repair is essential to cell survival. In skeletal muscle, injury often associates with
plasma membrane disruption. Additionally, muscular dystrophy is linked to mutations in …

Membrane instability and disruption underlie myriad acute and chronic disorders. Anxa6
encodes the membrane-associated protein annexin A6 and was identified as a genetic …

Disruption of the plasma membrane often accompanies cellular injury, and in muscle,
plasma membrane resealing is essential for efficient recovery from injury. Muscle …

Defects in membrane repair contribute to the development of some muscular dystrophies,
highlighting the importance to decipher the membrane repair mechanisms in human skeletal …

Muscular dystrophies constitute a group of genetic disorders that cause weakness and
progressive loss of skeletal muscle mass. Among them, Miyoshi muscular dystrophy 1 …

Many monogenic disorders, including the muscular dystrophies, display phenotypic
variability despite the same disease-causing mutation. To identify genetic modifiers of …

Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair
requires the membrane protein dysferlin. We previously identified that, similar to dysferlin …

Plasma membrane wound repair is a cell-autonomous process that is triggered by Ca 2+
entering through the site of injury and involves membrane resealing, ie, re-establishment of …

Repair and regeneration of the injured skeletal myofiber involves fusion of intracellular
vesicles with sarcolemma and fusion of the muscle progenitor cells respectively. In vitro …

The annexins, a family of Ca 2+-and lipid-binding proteins, are involved in a range of
intracellular processes. Recent findings have implicated annexin A1 in the resealing of …