Context: Thyroid cancer incidence rates in the United States and globally have increased
steadily over the last 40 years, primarily due to a tripling of the incidence of papillary thyroid …

Objective Genetic alterations in four oncogenes, namely RAS point mutations, RET
rearrangements (RET/PTC), NTRK1 rearrangements (TRK) and BRAF point mutations have …

Recent advances in molecular diagnostics have led to significant insights into the genetic
basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the …

Summary Purpose BRAF V600E mutation represents the most common oncogenic event in
sporadic papillary thyroid cancer (PTC). There are, however, significant discrepancies …

Objectives The genes RET and RAS, and more recently BRAF, have been shown to be
frequently mutated in human papillary thyroid carcinomas (PTC). The aim of this study was …

BACKGROUND: The incidence of thyroid cancer has doubled over the past decade. The
reason for this dramatic increase in incidence is controversial. Some investigators have …

Context: Evaluation of the degree of neoplastic infiltration beyond the thyroid capsule
remains a unique parameter that can be evaluated by histopathological examination to label …

Context: Because very few studies have examined the correlation between BRAF mutations
and clinicopathological features of papillary thyroid carcinoma (PTC), we analyzed here a …

Context: Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve
risk stratification of this cancer. Objective: The objective of the study was to investigate the …

Summary Background The activating BRAFV600E mutation is the most common genetic
alteration reported in papillary thyroid carcinoma (PTC). While some reports suggest the …