Fluoride (F) exposure can cause osteosclerosis, which is characterised by a high bone
mass, but its mechanism is not fully illustrated. Here, we aimed to evaluate the effects of …

Excess fluoride in drinking water is an environmental issue of increasing worldwide concern,
because of its adverse effect on human health. Skeletal fluorosis caused by chronic …

Although fluoride is known to stimulate bone formation, the underlying mechanisms are not
fully understood. Recent studies have implicated the Wnt/β-catenin pathway as a major …

Fluorine is widely present in nature in the form of fluoride. Prolonged high-dose fluoride
exposure can cause skeletal fluorosis, resulting in osteosclerosis, osteoporosis or …

While it has been well-documented that excessive fluoride exposure caused the skeletal
disease and osteoblasts played a critical role in the advanced skeletal fluorosis, the …

Exposure to excessive fluoride poses a threat to human health, including increased
susceptibility to developing the skeletal fluorosis. Despite its recognized importance as an …

Globally, 200 million people are suffering from toxic manifestations of Fluoride (F), dental
and skeletal fluorosis; unfortunately, there is no treatment. To unravel the pathogenesis of …

Excessive systemic uptake of inorganic fluorides causes disturbances of bone homeostasis.
The mechanism of skeletal fluorosis is still uncertain. This study aimed to study the effect of …

Long-term excessive intake of fluoride (F) could lead to chronic fluorosis. To explore the
underlying molecular mechanisms, present study is designed to elucidate the effect of …

Fluorosis and bone pathologies can be caused by chronic and/or excessive fluoride intake.
Despite this, few studies have been conducted on the cellular mechanisms underlying …