Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

Progresses in medicinal chemistry over the last few years have focused on the design and
synthesis of hybrid compounds, molecules encompassing in a single scaffold two …

Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …

Alzheimer's disease is a complex neurodegenerative disorder with a multifaceted
pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs …

Alzheimer's disease (AD) is a complex neurodegenerative condition with several target
proteins contributing to its etiology. With 35.6 million cases worldwide documented in 2011 …

The cholinergic hypothesis has long been a “polar star” in drug discovery for Alzheimer's
disease (AD), resulting in many small molecules and biological drug candidates. Most of the …

Our present work demonstrates the successful design and synthesis of a new class of
compounds based upon a multitargeted directed ligand design approach to discover new …

Alzheimer's disease (AD) is one of the most complex progressive neurological disorders
involving degeneration of neuronal connections in brain cells leading to cell death. AD is …

Exploring small-molecule acetylcholinesterase (AChE) inhibitors to slow the breakdown of
acetylcholine (Ach) represents the mainstream direction for Alzheimer's disease (AD) …

The multifactorial nature of Alzheimer's disease (AD) is a reason for the lack of effective
drugs as well as a basis for the development of “multi-target-directed ligands”(MTDLs). As …