Enhanced photodynamic efficiency achieved via a dual-targeted strategy based on photosensitizer/micelle structure

J Xu, F Zeng, H Wu, C Hu, S Wu - Biomacromolecules, 2014 - ACS Publications
The applications of photodynamic therapy (PDT) are usually limited by photosensitizer's side
effect and the singlet oxygen's short half-life. Herein, we demonstrate a dual-targeting (both …

Dual-targeting nanosystem for enhancing photodynamic therapy efficiency

J Xu, F Zeng, H Wu, C Yu, S Wu - ACS Applied Materials & …, 2015 - ACS Publications
Photodynamic therapy (PDT) has been recognized as a valuable treatment option for
localized cancers. Herein, we demonstrate a cellular and subcellular targeted strategy to …

Mitochondria-targeting and multiresponsive nanoplatform based on aiegens for synergistic chemo-photodynamic therapy and enhanced immunotherapy

Q Feng, J Xu, C Zhuang, J Xiong, H Wang… - …, 2023 - ACS Publications
Although photodynamic therapy (PDT) has become an attractive strategy for cancer
treatment, its clinical application still suffers from some limitations, including insufficient …

Photoactivation switch from type II to type I reactions by electron-rich micelles for improved photodynamic therapy of cancer cells under hypoxia

H Ding, H Yu, Y Dong, R Tian, G Huang… - Journal of Controlled …, 2011 - Elsevier
Photodynamic therapy (PDT) is an emerging clinical modality for the treatment of a variety of
diseases. Most photosensitizers are hydrophobic and poorly soluble in water. Many new …

A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy

T Qi, B Chen, Z Wang, H Du, D Liu, Q Yin, B Liu… - Biomaterials, 2019 - Elsevier
Mitochondria-targeted photodynamic therapy (PDT) has emerged as one of the most
efficient antitumor strategies. However, the therapeutic outcome of mitochondria-targeted …

A redox stimulation-activated amphiphile for enhanced photodynamic therapy

Y Xue, J Tian, Z Liu, J Chen, M Wu, Y Shen… - …, 2019 - ACS Publications
The development of more efficient photosensitizers with minimal damage to surrounding
normal tissues has been a valuable and challenging subject during photodynamic therapy …

A BODIPY-modified polymeric micelle for sustaining enhanced photodynamic therapy

YC Zhang, L She, ZY Xu, ZK Wang, Z Ma, F Yang… - Chinese Chemical …, 2022 - Elsevier
Photodynamic therapy (PDT) has been gaining popularity in both scientific research and
clinic applications due to its non-invasiveness and spatiotemporal targeting properties …

Glycopolymeric photosensitizers with cholic acid for HepG2-targeted chemo-photodynamic synergistic therapy

M Yu, R Wang, Z Ma, M Zhu - Biomacromolecules, 2023 - ACS Publications
The aggregation-caused quenching, premature drug release, and hypoxia-caused
resistance of photodynamic therapy (PDT) are challenges in the design and preparation of …

Supramolecular micelles as multifunctional theranostic agents for synergistic photodynamic therapy and hypoxia-activated chemotherapy

X Huang, T Chen, N Mu, HW Lam, C Sun, L Yue… - Acta biomaterialia, 2021 - Elsevier
Photodynamic therapy (PDT), where a photosensitizer (under light irradiation) converts
molecular oxygen to singlet oxygen to elicit programmed cell death, is a promising cancer …

Poly (photosensitizer) nanoparticles for enhanced in vivo photodynamic therapy by interrupting the π–π stacking and extending circulation time

N Zheng, Z Zhang, J Kuang, C Wang… - … applied materials & …, 2019 - ACS Publications
The natural planar and rigid structures of most of the hydrophobic photosensitizers
(PSs)[such as tetraphenyl porphyrin (TPP)] significantly reduce their loading efficiencies in …