The ciliopathies are an apparently disparate group of human diseases that all result from
defects in the formation and/or function of cilia. They include disorders such as Meckel …

Primary (nonmotile) cilia are currently enjoying a renaissance in light of novel ascribed
functions ranging from mechanosensory to signal transduction. Their importance for key …

Soon, the genetic basis of most human Mendelian diseases will be solved. The next
challenge will be to leverage this information to uncover basic mechanisms of disease and …

Cilia and flagella are ancient, evolutionarily conserved organelles that project from cell
surfaces to perform diverse biological roles, including whole-cell locomotion; movement of …

Over the last 5 years, disorders of nonmotile cilia have come of age and their study has
contributed immeasurably to our understanding of cell biology and human genetics. This …

Cilia and flagella are highly conserved and important microtubule-based organelles that
project from the surface of eukaryotic cells and act as antennae to sense extracellular …

Mutations in genes encoding cilia proteins cause human ciliopathies, diverse disorders
affecting many tissues. Individual genes can be linked to ciliopathies with dramatically …

Ubiquitous in nature, cilia and flagella comprise nearly identical structures with similar
functions. The most obvious example of the latter is motility: driving movement of the …

Cilia, microtubule-based structures found on the surface of almost all vertebrate cells, play
an array of diverse biological functions. Abnormal ciliary axonemal structure and function …

In light of the growing list of human disorders associated with their dysfunction, primary cilia
have recently come to attention as being important regulators of developmental signaling …