Altered serum uric acid concentrations, both above and below normal levels, have been
linked to a number of disease states. An abnormally high uric acid level has been correlated …

Recent progress in the understanding of purine metabolism and uric acid disposition is
reviewed and a rational classification based on uric acid production is suggested to provide …

Increased levels of uric acid are associated with cardiovascular disease and the metabolic
syndrome. They may predict clinical outcomes and also the onset of hypertension, though it …

Uric acid metabolism is an important concern in many clinical disciplines. Just as" all that
wheezes is not asthma," all hyperuricemia is not gout. Clearly, altered urate metabolism is …

High uric acid (UA) levels can cause gout, urolithiasis and acute and chronic nephropathy,
all of which are due to the deposit of urate crystals. There is also increasing evidence of …

After uric acid was recognized as the causative factor in gout, increased prevalence of renal
disease and hypertension in this patient population caught the attention of the medical …

Background and Purpose—High normal concentrations of serum uric acid (UA) are
associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by …

Uric acid was first associated with primary hypertension in 1874, yet its role in this condition
remains unclear. Historically, uric acid was thought to be a secondary response to …

In humans, uric acid is the final oxidation product of purine catabolism. The serum uric acid
level is based on the balance between the absorption, production and excretion of purine …

An elevation in circulating serum uric acid is strongly associated with the development of
hypertension and renal disease, but whether uric acid has a causal role or whether it simply …