Background and objective: We explored which clinical and biochemical variables predict
conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis …

Significant cognitive impairment has been found in 20—30% of patients with clinically
isolated syndromes suggestive of multiple sclerosis. In this study we aimed to assess the …

Clinically isolated syndrome (CIS) is a central nervous system demyelinating event isolated
in time that is compatible with the possible future development of multiple sclerosis (MS) …

Aim of the study: To evaluate and compare the capacity of oligoclonal bands (OB) and three
sets of MR imaging criteria to predict the conversion of clinically isolated syndromes (CIS) to …

We reviewed the records of 391 patients who had presented with a Clinically Isolated
Syndrome and selected 205 who had performed a baseline spinal tap and MRI scan. We …

Objective: To explore the long-term outcomes of patients with clinically isolated syndromes
from the Barcelona cohort. Methods: We selected patients with a follow-up longer than 10 …

This paper extends on previous data on prognosis in multiple sclerosis (MS), to encompass
the entire course of the disease. The first episode suggestive of MS [the clinically isolated …

Natural history studies have identified factors that predict evolution to multiple sclerosis or
risk of disability accumulation over time. Although these studies are based on large …

Clinically isolated syndrome (CIS) is a term that describes a first clinical episode with
features suggestive of multiple sclerosis (MS). It usually occurs in young adults and affects …

Clinically isolated syndrome (CIS) refers to the earliest clinical manifestation of multiple
sclerosis (MS). Currently there are no prognostic biological markers that accurately predict …