PI3K/Akt/mTOR signaling pathway and the biphasic effect of arsenic in carcinogenesis
Arsenic is a naturally occurring, ubiquitous metalloid found in the Earth's crust. In its
inorganic form, arsenic is highly toxic and carcinogenic and is widely found across the globe …
inorganic form, arsenic is highly toxic and carcinogenic and is widely found across the globe …
New perspectives in arsenic-induced cell signal transduction
Y Qian, V Castranova, X Shi - Journal of inorganic biochemistry, 2003 - Elsevier
Although the carcinogenicity of arsenic has been well established, the underlying molecular
mechanisms have not yet been fully identified. Accumulating evidence indicates that the …
mechanisms have not yet been fully identified. Accumulating evidence indicates that the …
Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis
C Yang, K Frenkel - Journal of environmental pathology …, 2002 - dl.begellhouse.com
Arsenic is a common environmental and occupational pollutant and a wellknown human
carcinogen that causes cancers in many human organs. The exact molecular mechanisms …
carcinogen that causes cancers in many human organs. The exact molecular mechanisms …
Oxidative stress, epigenetics, and cancer stem cells in arsenic carcinogenesis and prevention
L Li, F Chen - Current pharmacology reports, 2016 - Springer
The carcinogenic role of arsenic has been extensively studied for more than half century.
How arsenic causes human cancer, however, remains to be fully elucidated. In this brief …
How arsenic causes human cancer, however, remains to be fully elucidated. In this brief …
Molecular mechanisms of arsenic carcinogenesis
C Huang, Q Ke, M Costa, X Shi - Molecular and cellular biochemistry, 2004 - Springer
Arsenic is a metalloid compound that is widely distributed in the environment. Human
exposure of this compound has been associated with increased cancer incidence. Although …
exposure of this compound has been associated with increased cancer incidence. Although …
Arsenic and cancer: Evidence and mechanisms
Arsenic is a potent carcinogen and poses a significant health concern worldwide. Exposure
occurs through ingestion of drinking water and contaminated foods and through inhalation …
occurs through ingestion of drinking water and contaminated foods and through inhalation …
Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma
Bidirectional cancer-promoting and anti-cancer effects of arsenic for cancer cells have been
revealed in previous studies. However, each of these effects (cancer-promoting or anti …
revealed in previous studies. However, each of these effects (cancer-promoting or anti …
Arsenic-induced epigenetic changes in cancer development
WN Saintilnord, Y Fondufe-Mittendorf - Seminars in cancer biology, 2021 - Elsevier
Arsenic is a ubiquitous metalloid whose high levels of toxicity pose major health concerns to
millions of people worldwide by increasing susceptibility to various cancers and non-cancer …
millions of people worldwide by increasing susceptibility to various cancers and non-cancer …
Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells
ATY Lau, M Li, R Xie, QY He, JF Chiu - Carcinogenesis, 2004 - academic.oup.com
Arsenic is a well-known carcinogen that possibly promotes tumors and the development of
various types of cancer in individuals chronically exposed to arsenic in their work or living …
various types of cancer in individuals chronically exposed to arsenic in their work or living …
Arsenic trioxide affects signal transducer and activator of transcription proteins through alteration of protein tyrosine kinase phosphorylation
M Wetzler, MT Brady, E Tracy, ZR Li, KA Donohue… - Clinical cancer …, 2006 - AACR
Purpose: Arsenic trioxide decreases proliferation of acute myeloid leukemia (AML) cells, but
its precise mechanism of action is unknown. Experimental Design: We studied the effect of …
its precise mechanism of action is unknown. Experimental Design: We studied the effect of …