Future antimicrobials: Natural and functionalized phenolics

A Lobiuc, NE Pavăl, II Mangalagiu, R Gheorghiță… - Molecules, 2023 - mdpi.com
With incidence of antimicrobial resistance rising globally, there is a continuous need for
development of new antimicrobial molecules. Phenolic compounds having a versatile …

Preventing microbial infections with natural phenolic compounds

K Ecevit, AA Barros, JM Silva, RL Reis - Future Pharmacology, 2022 - mdpi.com
The struggle between humans and pathogens has taken and is continuing to take countless
lives every year. As the misusage of conventional antibiotics increases, the complexity …

Antimicrobial capacity of plant polyphenols against gram-positive bacteria: A comprehensive review

FJ Álvarez-Martínez, E Barrajón-Catalán… - Current medicinal …, 2020 - ingentaconnect.com
Background: Multi-drug-resistant bacteria such as Methicillin-Resistant Staphylococcus
aureus (MRSA) disseminate rapidly amongst patients in healthcare facilities and suppose …

[HTML][HTML] General overview of phenolics from plant to laboratory, good antibacterials or not

OA Aldulaimi - Pharmacognosy Reviews, 2017 - ncbi.nlm.nih.gov
The emergence and rapid development of seriously drug-resistant pathogens have created
the greatest danger to public health and made the treatment of infectious diseases …

Polyphenols as antimicrobial agents

M Daglia - Current opinion in biotechnology, 2012 - Elsevier
Polyphenols are secondary metabolites produced by higher plants, which play multiple
essential roles in plant physiology and have potential healthy properties on human …

Synthetic flavonoids with antimicrobial activity: a review

LG Sarbu, LG Bahrin, C Babii, M Stefan… - Journal of applied …, 2019 - academic.oup.com
The emergence of drug‐resistant microbes left us with a great need for new antimicrobial
agents. Flavonoids, with their wide range of biological activities, are good candidates in this …

The potential of systems biology to discover antibacterial mechanisms of plant phenolics

CS Rempe, KP Burris, SC Lenaghan… - Frontiers in …, 2017 - frontiersin.org
Drug resistance of bacterial pathogens is a growing problem that can be addressed through
the discovery of compounds with novel mechanisms of antibacterial activity. Natural …

Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants

W Huang, Y Wang, W Tian, X Cui, P Tu, J Li, S Shi… - Antibiotics, 2022 - mdpi.com
The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …

Antibacterial effects of flavonoids and their structure-activity relationship study: A comparative interpretation

NF Shamsudin, QU Ahmed, S Mahmood, SA Ali Shah… - Molecules, 2022 - mdpi.com
According to the latest report released by the World Health Organization, bacterial
resistance to well-known and widely available antibacterial drugs has become a significant …

Plant natural products targeting bacterial virulence factors

LN Silva, KR Zimmer, AJ Macedo, DS Trentin - Chemical reviews, 2016 - ACS Publications
Decreased antimicrobial efficiency has become a global public health issue. The paucity of
new antibacterial drugs is evident, and the arsenal against infectious diseases needs to be …