Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse
biological functions and have a role in various conditions, such as cerebral and cardiac …

The interest on targeting adenosine A2A receptors in the realm of psychiatric diseases first
arose based on their tight physical and functional interaction with dopamine D2 receptors …

The adenosine A2A receptor (A2AR) is in the center of a neuromodulatory network affecting
a wide range of neuropsychiatric functions by interacting with and integrating several …

Endogenous adenosine is a widely distributed upstream regulator of a broad spectrum of
neurotransmitters, receptors, and signaling pathways that converge to contribute to the …

When administered to normal healthy patients, a nonselective adenosine A 1/A 2A
antagonist, caffeine, tended to improve anxiety and depression at low doses and to …

Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia,
activated by the neuromodulator adenosine, which interact with dopamine D2 receptors …

Adenosine, an ubiquitous neuromodulator, and its analogues have been shown to produce
'depressant'effects in animal models believed to be relevant to depressive disorders, while …

Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various …

Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for
the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists …

Adenosine exerts an important role in the modulation of central nervous system (CNS)
activity. Through the interaction with four G-protein coupled receptor (GPCR) subtypes …